Jason L Rowand
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Explore the profile of Jason L Rowand including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
157
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Recent Articles
1.
Sabbatini P, Korenchuk S, Rowand J, Groy A, Liu Q, Leperi D, et al.
Mol Cancer Ther
. 2009 Oct;
8(10):2811-20.
PMID: 19825801
The insulin-like growth factor-I receptor (IGF-IR) signaling pathway is activated in various tumors, and inhibition of IGF-IR kinase provides a therapeutic opportunity in these patients. GSK1838705A is a small-molecule kinase...
2.
Sabbatini P, Rowand J, Groy A, Korenchuk S, Liu Q, Atkins C, et al.
Clin Cancer Res
. 2009 Apr;
15(9):3058-67.
PMID: 19383820
Purpose: Dysregulation of the insulin-like growth factor-I receptor (IGF-IR) signaling pathway has been implicated in the development of many types of tumors, including prostate, colon, breast, pancreatic, ovarian, and sarcomas....
3.
Emmitte K, Wilson B, Baum E, Emerson H, Kuntz K, Nailor K, et al.
Bioorg Med Chem Lett
. 2008 Dec;
19(3):1004-8.
PMID: 19101143
The optimization of imidazo[1,2-a]pyridine inhibitors as potent and selective inhibitors of IGF-1R is presented. Further optimization of oral exposure in mice is also discussed. Detailed selectivity, in vitro activity, and...
4.
Chamberlain S, Redman A, Wilson J, DeAnda F, Shotwell J, Gerding R, et al.
Bioorg Med Chem Lett
. 2008 Dec;
19(2):360-4.
PMID: 19071018
The SAR of C5' functional groups with terminal basic amines at the C6 aniline of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines is reported. Examples demonstrate potent inhibition of IGF-1R with 1000-fold selectivity over JNK1 and...
5.
Chamberlain S, Wilson J, DeAnda F, Patnaik S, Redman A, Yang B, et al.
Bioorg Med Chem Lett
. 2008 Dec;
19(2):469-73.
PMID: 19056263
The evaluation of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines as inhibitors of the IGF-1R (IGF-IR) receptor tyrosine kinase is reported. Examples demonstrate nanomolar potencies in in vitro enzyme and mechanistic cellular assays...
6.
Rowand J, Martin G, Doyle G, Miller M, Pierce M, Connelly M, et al.
Cytometry A
. 2007 Jan;
71(2):105-13.
PMID: 17226859
Background: A lack of standardized assays and consensus of cell definition has lead to a wide variation in the reported range of circulating endothelial cells (CECs). Methods: An automated rare...