Jason I Griffiths
Overview
Explore the profile of Jason I Griffiths including associated specialties, affiliations and a list of published articles.
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14
Citations
199
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Recent Articles
1.
Griffiths J, Cosgrove P, Medina E, Nath A, Chen J, Adler F, et al.
Nat Commun
. 2025 Mar;
16(1):2132.
PMID: 40032842
Immune evasion by cancer cells involves reshaping the tumor microenvironment (TME) via communication with non-malignant cells. However, resistance-promoting interactions during treatment remain lesser known. Here we examine the composition, communication,...
2.
Adler F, Griffiths J
Semin Cancer Biol
. 2025 Jan;
109:91-100.
PMID: 39890041
Background And Objectives: The development and regulation of healthy and cancerous breast tissue is guided by communication between cells. Diverse signals are exchanged between cancer cells and non-cancerous cells of...
3.
Singhal A, Zhao X, Wall P, So E, Calderini G, Partin A, et al.
Cancer Discov
. 2025 Jan;
15(2):271-285.
PMID: 39760657
As the field of artificial intelligence evolves rapidly, these hallmarks are intended to capture fundamental, complementary concepts necessary for the progress and timely adoption of predictive modeling in precision oncology....
4.
Jitmana K, Griffiths J, Fereday S, DeFazio A, Bowtell D, Adler F
PLoS Comput Biol
. 2024 May;
20(5):e1012073.
PMID: 38809938
A time-series analysis of serum Cancer Antigen 125 (CA-125) levels was performed in 791 patients with high-grade serous ovarian cancer (HGSOC) from the Australian Ovarian Cancer Study to evaluate the...
5.
Chi F, Griffiths J, Nath A, Bild A
Breast Cancer Res
. 2024 Mar;
26(1):54.
PMID: 38553760
Fibroblast growth factors (FGFs) control various cellular functions through fibroblast growth factor receptor (FGFR) activation, including proliferation, differentiation, migration, and survival. FGFR amplification in ER + breast cancer patients correlate...
6.
Liu X, Griffiths J, Bishara I, Liu J, Bild A, Chang J
Sci Rep
. 2023 Aug;
13(1):12854.
PMID: 37553438
Tumors are comprised of subpopulations of cancer cells that harbor distinct genetic profiles and phenotypes that evolve over time and during treatment. By reconstructing the course of cancer evolution, we...
7.
Emond R, Griffiths J, Grolmusz V, Nath A, Chen J, Medina E, et al.
Nat Commun
. 2023 Jun;
14(1):3851.
PMID: 37386030
The interplay of positive and negative interactions between drug-sensitive and resistant cells influences the effectiveness of treatment in heterogeneous cancer cell populations. Here, we study interactions between estrogen receptor-positive breast...
8.
Bishara I, Chen J, Griffiths J, Bild A, Nath A
Front Genet
. 2022 Dec;
13:982019.
PMID: 36506328
Recent advances in single cell RNA sequencing (scRNA-seq) technologies have been invaluable in the study of the diversity of cancer cells and the tumor microenvironment. While scRNA-seq platforms allow processing...
9.
Pishas K, Cowley K, Pandey A, Hoang T, Beach J, Luu J, et al.
Cancers (Basel)
. 2021 Nov;
13(22).
PMID: 34830797
Despite high response rates to initial chemotherapy, the majority of women diagnosed with High-Grade Serous Ovarian Cancer (HGSOC) ultimately develop drug resistance within 1-2 years of treatment. We previously identified...
10.
Griffiths J, Chen J, Cosgrove P, ODea A, Sharma P, Ma C, et al.
Nat Cancer
. 2021 Oct;
2(6):658-671.
PMID: 34712959
Combining cyclin-dependent kinase (CDK) inhibitors with endocrine therapy improves outcomes for metastatic estrogen receptor positive (ER+) breast cancer patients but its value in earlier stage patients is unclear. We examined...