Jason Flannick
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Explore the profile of Jason Flannick including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes
Kwak S, Srinivasan S, Chen L, Todd J, Mercader J, Jensen E, et al.
Res Sq
. 2023 Jun;
PMID: 37292813
Youth-onset type 2 diabetes (T2D) is a growing public health concern. Its genetic basis and relationship to other forms of diabetes are largely unknown. To gain insight into the genetic...
12.
Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch A, Zhu W, Petty L, et al.
Diabetologia
. 2023 May;
66(7):1273-1288.
PMID: 37148359
Aims/hypothesis: The Latino population has been systematically underrepresented in large-scale genetic analyses, and previous studies have relied on the imputation of ungenotyped variants based on the 1000 Genomes (1000G) imputation...
13.
Han S, McNulty M, Benway C, Wen P, Greenberg A, Onuchic-Whitford A, et al.
Nat Commun
. 2023 Apr;
14(1):2229.
PMID: 37076491
Expression quantitative trait locus (eQTL) studies illuminate genomic variants that regulate specific genes and contribute to fine-mapped loci discovered via genome-wide association studies (GWAS). Efforts to maximize their accuracy are...
14.
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al.
Cell Metab
. 2023 Apr;
35(5):887-905.e11.
PMID: 37075753
Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-associated diseases. However, there are no scalable approaches to comprehensively assess the diverse FFAs circulating in human...
15.
Costanzo M, von Grotthuss M, Massung J, Jang D, Caulkins L, Koesterer R, et al.
Cell Metab
. 2023 Mar;
35(4):695-710.e6.
PMID: 36963395
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories of these data seek to be disease-agnostic and therefore lack disease-focused views. The...
16.
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al.
bioRxiv
. 2023 Mar;
PMID: 36865221
Highlights: FALCON (Fatty Acid Library for Comprehensive ONtologies) enables multimodal profiling of 61 free fatty acids (FFAs) to reveal 5 FFA clusters with distinct biological effectsFALCON is applicable to many...
17.
Aragam K, Jiang T, Goel A, Kanoni S, Wolford B, Atri D, et al.
Nat Genet
. 2022 Dec;
54(12):1803-1815.
PMID: 36474045
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease...
18.
Dornbos P, Koesterer R, Ruttenburg A, Nguyen T, Cole J, Leong A, et al.
Nat Genet
. 2022 Oct;
54(11):1609-1614.
PMID: 36280733
Polygenic scores (PGSs) combine the effects of common genetic variants to predict risk or treatment strategies for complex diseases. Adding rare variation to PGSs has largely unknown benefits and is...
19.
Zhang J, Chen W, Chen G, Flannick J, Fikse E, Smerin G, et al.
Hum Mol Genet
. 2022 Oct;
33(8):655-666.
PMID: 36255737
How ancestry-associated genetic variance affects disparities in the risk of polygenic diseases and influences the identification of disease-associated genes warrants a deeper understanding. We hypothesized that the discovery of genes...
20.
Zhong S, Chevre R, Mayan D, Corliano M, Cochran B, Sem K, et al.
J Clin Invest
. 2022 Sep;
132(21).
PMID: 36107630
BACKGROUNDCytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated bile acids (BAs) that are associated with insulin resistance in humans.METHODSTo determine whether reduced CYP8B1 activity improves insulin sensitivity,...