Jason C Wong
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Explore the profile of Jason C Wong including associated specialties, affiliations and a list of published articles.
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22
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681
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Recent Articles
11.
Lin X, Chen W, Qiu Z, Guo L, Zhu W, Li W, et al.
J Med Chem
. 2015 Mar;
58(6):2809-20.
PMID: 25734520
Histone deacetylase 6 (HDAC6) removes the acetyl group from lysine residues in a number of non-histone substrates and plays important roles in microtubule dynamics and chaperone activities. There is growing...
12.
Tang G, Wong J, Zhang W, Wang Z, Zhang N, Peng Z, et al.
J Med Chem
. 2014 Sep;
57(19):8026-34.
PMID: 25238284
Herein we report the identification of a novel class of HDAC6 and HDAC8 selective inhibitors through a unique chemistry and phenotypic screening strategy. Tetrahydroisoquinoline 12 was identified as a potent...
13.
Zhang Z, Lin Z, Zhou Z, Shen H, Yan S, Mayweg A, et al.
ACS Med Chem Lett
. 2014 Sep;
5(9):993-8.
PMID: 25221655
The YAP-TEAD protein-protein interaction (PPI) mediates the oncogenic function of YAP, and inhibitors of this PPI have potential usage in treatment of YAP-involved cancers. Here we report the design and...
14.
Shen Q, Wu J, Wong J
Drug Discov Today
. 2013 Sep;
18(23-24):1334-41.
PMID: 24012972
Diabetic retinopathy (DR) is of great interest to the drug discovery community owing to the rising worldwide prevalence of diabetes and its associated complications. The complex molecular mechanism associated with...
15.
Wong J, Tang G, Wu X, Liang C, Zhang Z, Guo L, et al.
J Med Chem
. 2012 Oct;
55(20):8903-25.
PMID: 23061376
Herein, we describe the pharmacokinetic optimization of a series of class-selective histone deacetylase (HDAC) inhibitors and the subsequent identification of candidate predictive biomarkers of hepatocellular carcinoma (HCC) tumor response for...
16.
Wong J, Guo L, Peng Z, Zhang W, Zhang N, Lai W, et al.
Bioorg Med Chem Lett
. 2010 Dec;
21(1):110-6.
PMID: 21145737
Novel 2-aminoanilide histone deacetylase (HDAC) inhibitors were designed to increase their contact with surface residues surrounding the HDAC active site compared to the contacts made by existing clinical 2-aminoanilides such...
17.
Haggarty S, Clemons P, Wong J, Schreiber S
Comb Chem High Throughput Screen
. 2004 Dec;
7(7):669-76.
PMID: 15578929
An objective of chemical genetics is to understand the relationships between the structures of small molecules and their phenotypic effects in intact living systems. We present here the results of...
18.
Wong J, Sternson S, Louca J, Hong R, Schreiber S
Chem Biol
. 2004 Sep;
11(9):1279-91.
PMID: 15380188
Modular synthesis and substrate stereocontrol were combined to furnish 18,000 diverse 1,3-dioxanes whose distribution in chemical space rivals that of a reference set of over 2,000 bioactive small molecules. Library...
19.
Koeller K, Haggarty S, Perkins B, Leykin I, Wong J, Kao M, et al.
Chem Biol
. 2003 May;
10(5):397-410.
PMID: 12770822
Histone deacetylase (HDAC) inhibitors are being developed as new clinical agents in cancer therapy, in part because they interrupt cell cycle progression in transformed cell lines. To examine cell cycle...
20.
Haggarty S, Koeller K, Wong J, Butcher R, Schreiber S
Chem Biol
. 2003 May;
10(5):383-96.
PMID: 12770821
Systematic chemical genetics aims to explore the space representing interactions between small molecules and biological systems. Beyond measuring binding interactions and enzyme inhibition, measuring changes in the activity of proteins...