Jason C OConnor
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Explore the profile of Jason C OConnor including associated specialties, affiliations and a list of published articles.
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62
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5238
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Recent Articles
21.
Rodriguez-Zas S, Wu C, Southey B, OConnor J, Nixon S, Garcia R, et al.
Psychoneuroendocrinology
. 2018 Jul;
97:47-58.
PMID: 30005281
Background: Peripheral immune challenge can elicit microglia activation and depression-related symptoms. The balance of inflammatory signals in the tryptophan pathway can skew the activity of indoleamine-pyrrole 2,3 dioxygenase (IDO1) towards...
22.
Garrison A, Parrott J, Tunon A, Delgado J, Redus L, OConnor J
Psychoneuroendocrinology
. 2018 May;
94:1-10.
PMID: 29734055
Chronic stress or inflammation increases tryptophan metabolism along the kynurenine pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to subsequent depressive-like behaviors. Microglia regulate KP balance by preferentially...
23.
Chen C, Li X, Ge G, Liu J, Biju K, Laing S, et al.
Sci Rep
. 2018 Apr;
8(1):5460.
PMID: 29615705
Glial cell line-derived neurotrophic factor (GDNF) is the most potent neuroprotective agent tested in cellular and animal models of Parkinson's disease (PD). However, CNS delivery of GDNF is restricted by...
24.
Bai J, Cervantes C, Liu J, He S, Zhou H, Zhang B, et al.
Proc Natl Acad Sci U S A
. 2017 Nov;
114(46):12196-12201.
PMID: 29087318
Chronic inflammation in adipose tissue plays a key role in obesity-induced insulin resistance. However, the mechanisms underlying obesity-induced inflammation remain elusive. Here we show that obesity promotes mtDNA release into...
25.
Laumet G, Zhou W, Dantzer R, Edralin J, Huo X, Budac D, et al.
Brain Behav Immun
. 2017 Jul;
66:94-102.
PMID: 28709913
Pain and depression often co-occur, but the underlying mechanisms have not been elucidated. Here, we used the spared nerve injury (SNI) model in mice to induce both neuropathic pain and...
26.
Debnath S, Velagapudi C, Redus L, Thameem F, Kasinath B, Hura C, et al.
Int J Tryptophan Res
. 2017 May;
10:1178646917694600.
PMID: 28469469
Objective: Type 2 diabetes (T2D) is the primary case of chronic kidney disease (CKD). Inflammation is associated with metabolic dysregulation in patients with T2D and CKD. Tryptophan (TRP) metabolism may...
27.
Parrott J, Redus L, OConnor J
J Neuroinflammation
. 2016 May;
13(1):124.
PMID: 27233247
Background: Inflammation increases the risk of developing depression-related symptoms, and tryptophan metabolism is an important mediator of these behavior changes. Peripheral immune activation results in central up-regulation of pro-inflammatory cytokine...
28.
Gonzalez-Pena D, Nixon S, OConnor J, Southey B, Lawson M, McCusker R, et al.
PLoS One
. 2016 Mar;
11(3):e0150858.
PMID: 26959683
Depression symptoms following immune response to a challenge have been reported after the recovery from sickness. A RNA-Seq study of the dysregulation of the microglia transcriptome in a model of...
29.
Sareddy G, Zhang Q, Wang R, Scott E, Zou Y, OConnor J, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
112(48):E6673-82.
PMID: 26627258
17-β estradiol (E2) has been implicated as neuroprotective in a variety of neurodegenerative disorders. However, the underlying mechanism remains unknown. Here, we provide genetic evidence, using forebrain-specific knockout (FBKO) mice,...
30.
Parrott J, OConnor J
Front Psychiatry
. 2015 Sep;
6:116.
PMID: 26347662
Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders. The kynurenine pathway consists of two functionally distinct branches...