Jascha-N Rybak
Overview
Explore the profile of Jascha-N Rybak including associated specialties, affiliations and a list of published articles.
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9
Citations
371
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Recent Articles
1.
Rosli C, Rybak J, Neri D, Elia G
Methods Mol Biol
. 2008 Feb;
418:89-100.
PMID: 18287652
The strong interaction between streptavidin and biotin is one of the most commonly exploited tools in chemistry and biology. Methods for the facile derivatization of a variety of molecules (in...
2.
Villa A, Trachsel E, Kaspar M, Schliemann C, Sommavilla R, Rybak J, et al.
Int J Cancer
. 2008 Feb;
122(11):2405-13.
PMID: 18271006
The alternatively spliced extra-domain B of fibronectin is one of the best characterized markers of tumor angiogenesis. Similarly, the extra-domain A (EDA), which can also be inserted in the fibronectin...
3.
Rybak J, Roesli C, Kaspar M, Villa A, Neri D
Cancer Res
. 2007 Nov;
67(22):10948-57.
PMID: 18006840
One of the most promising new avenues for the development of more selective and efficacious cancer therapies relies on the antibody-mediated targeted delivery of bioactive agents (e.g., cytokines) to the...
4.
Roesli C, Neri D, Rybak J
Nat Protoc
. 2007 Apr;
1(1):192-9.
PMID: 17406232
Targeted delivery of bioactive molecules to diseased organs or tissues by means of binding molecules specific to markers of diseases represents a promising area of pharmaceutical intervention. The availability of...
5.
Rybak J, Trachsel E, Scheuermann J, Neri D
ChemMedChem
. 2006 Dec;
2(1):22-40.
PMID: 17154429
This review illustrates the basic principles of ligand-based vascular targeting and presents some of the most advanced results obtained in this field, not only in terms of biopharmaceuticals, which are...
6.
Castronovo V, Waltregny D, Kischel P, Roesli C, Elia G, Rybak J, et al.
Mol Cell Proteomics
. 2006 Jul;
5(11):2083-91.
PMID: 16861259
A promising avenue toward the development of more selective anticancer drugs consists in the targeted delivery of bioactive molecules to the tumor environment by means of binding molecules specific to...
7.
Scheurer S, Rybak J, Roesli C, Brunisholz R, Potthast F, Schlapbach R, et al.
Proteomics
. 2005 Jun;
5(11):2718-28.
PMID: 15986331
Membrane proteins play a central role in biological processes, but their separation and quantification using two-dimensional gel electrophoresis is often limited by their poor solubility and relatively low abundance. We...
8.
Rybak J, Ettorre A, Kaissling B, Giavazzi R, Neri D, Elia G
Nat Methods
. 2005 Mar;
2(4):291-8.
PMID: 15782212
We describe a new methodology, based on terminal perfusion of rodents with a reactive ester derivative of biotin that enables the covalent modification of proteins readily accessible from the bloodstream....
9.
Rybak J, Scheurer S, Neri D, Elia G
Proteomics
. 2004 Jul;
4(8):2296-9.
PMID: 15274123
The interaction between streptavidin and biotin is one of the most widely used tools in chemistry and biology. However, the release of biotinylated proteins from streptavidin resins remains a major...