Jarrett R Remsberg
Overview
Explore the profile of Jarrett R Remsberg including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
513
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Recent Articles
1.
Won S, Zhang Y, Reinhardt C, Hargis L, MacRae N, DeMeester K, et al.
Mol Cell
. 2024 Oct;
84(21):4125-4141.e10.
PMID: 39413792
Pioneer transcription factors (TFs) bind to and open closed chromatin, facilitating engagement by other regulatory factors involved in gene activation or repression. Chemical probes are lacking for pioneer TFs, which...
2.
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders
Liu Z, Remsberg J, Li H, Njomen E, DeMeester K, Tao Y, et al.
J Am Chem Soc
. 2024 Apr;
146(15):10393-10406.
PMID: 38569115
Covalent chemistry coupled with activity-based protein profiling (ABPP) offers a versatile way to discover ligands for proteins in native biological systems. Here, we describe a set of stereo- and regiochemically...
3.
Won S, Zhang Y, Reinhardt C, MacRae N, DeMeester K, Njomen E, et al.
bioRxiv
. 2024 Apr;
PMID: 38562719
Pioneer transcription factors (TFs) exhibit a specialized ability to bind to and open closed chromatin, facilitating engagement by other regulatory factors involved in gene activation or repression. Chemical probes are...
4.
Tao Y, Felber J, Zou Z, Njomen E, Remsberg J, Ogasawara D, et al.
Angew Chem Int Ed Engl
. 2023 Nov;
62(51):e202311924.
PMID: 37909922
5-Methylcytosine (m C) is an RNA modification prevalent on tRNAs, where it can protect tRNAs from endonucleolytic cleavage to maintain protein synthesis. The NSUN family (NSUN1-7 in humans) of RNA...
5.
Li H, Ma T, Remsberg J, Won S, DeMeester K, Njomen E, et al.
Nat Chem Biol
. 2023 Oct;
19(11):1320-1330.
PMID: 37783940
Covalent chemistry represents an attractive strategy for expanding the ligandability of the proteome, and chemical proteomics has revealed numerous electrophile-reactive cysteines on diverse human proteins. Determining which of these covalent...
6.
Lazear M, Remsberg J, Jaeger M, Rothamel K, Her H, DeMeester K, et al.
Mol Cell
. 2023 Apr;
83(10):1725-1742.e12.
PMID: 37084731
Most human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such "binding-first" assays affect protein...
7.
Kathman S, Koo S, Lindsey G, Her H, Blue S, Li H, et al.
Nat Chem Biol
. 2023 Mar;
19(7):825-836.
PMID: 36864190
Much of the human proteome is involved in mRNA homeostasis, but most RNA-binding proteins lack chemical probes. Here we identify electrophilic small molecules that rapidly and stereoselectively decrease the expression...
8.
Remsberg J, Suciu R, Zambetti N, Hanigan T, Firestone A, Inguva A, et al.
Nat Chem Biol
. 2021 Apr;
17(8):856-864.
PMID: 33927411
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but...
9.
Zambetti N, Firestone A, Remsberg J, Huang B, Wong J, Long A, et al.
Blood
. 2020 Mar;
135(20):1772-1782.
PMID: 32219446
Oncogenic RAS mutations pose substantial challenges for rational drug discovery. Sequence variations within the hypervariable region of Ras isoforms underlie differential posttranslational modification and subcellular trafficking, potentially resulting in selective...
10.
Wang Y, Dix M, Bianco G, Remsberg J, Lee H, Kalocsay M, et al.
Nat Chem
. 2019 Oct;
11(12):1113-1123.
PMID: 31659311
A fundamental challenge in chemical biology and medicine is to understand and expand the fraction of the human proteome that can be targeted by small molecules. We recently described a...