Jaroslav Vicar
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Explore the profile of Jaroslav Vicar including associated specialties, affiliations and a list of published articles.
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13
Citations
180
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Recent Articles
1.
Vrba J, Dolezel P, Vicar J, Ulrichova J
Toxicol In Vitro
. 2009 Apr;
23(4):580-8.
PMID: 19346183
The benzo[c]phenanthridine alkaloid sanguinarine has been studied for its antiproliferative activity in many cell types. Almost nothing however, is known about the cytotoxic effects of dihydrosanguinarine, a metabolite of sanguinarine....
2.
Zdarilova A, Vrublova E, Vostalova J, Klejdus B, Stejskal D, Proskova J, et al.
Food Chem Toxicol
. 2008 Oct;
46(12):3721-6.
PMID: 18930108
Macleaya cordata (Willd.) (Papaveraceae) is used as an active component in the natural feed additive Sangrovit. Sangrovit contains mixture of the intact aerial parts and the fraction of quaternary benzo[c]phenanthridine...
3.
Vrublova E, Vostalova J, Vecera R, Klejdus B, Stejskal D, Kosina P, et al.
Food Chem Toxicol
. 2008 May;
46(7):2546-53.
PMID: 18495316
The quaternary benzo[c]phenanthridine alkaloid sanguinarine (SG) is the main component of Sangrovit, a natural livestock feed additive. Dihydrosanguinarine (DHSG) has recently been identified as a SG metabolite in rat. The...
4.
Vrba J, Dolezel P, Vicar J, Modriansky M, Ulrichova J
Toxicol In Vitro
. 2008 Mar;
22(4):1008-17.
PMID: 18358694
A quaternary benzo[c]phenanthridine alkaloid chelerythrine displays a wide range of biological activities including cytotoxicity to normal and cancer cells. In contrast, less is known about the biological activity of dihydrochelerythrine,...
5.
Psotova J, Klejdus B, Vecera R, Kosina P, Kuban V, Vicar J, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2005 Nov;
830(1):165-72.
PMID: 16280262
Adult rats were orally administered with a single dose of sanguinarine (10 mg SA per 1 kg body weight) in 1.0 ml water. In the plasma and the liver, dihydrosanguinarine...
6.
Zajoncova L, Kosina P, Vicar J, Ulrichova J, Pec P
J Enzyme Inhib Med Chem
. 2005 Aug;
20(3):261-7.
PMID: 16119197
Inhibition of porcine pancreas and human saliva alpha-amylase (EC 3.2.1.1) by sanguinarine and chelerythrine was studied. The inhibition of alpha-amylase was assayed using a biosensor method which utilises a flow...
7.
Dvorak Z, Modriansky M, Simanek V, Ulrichova J, Vicar J, Vrba J, et al.
Toxicol Lett
. 2005 Jul;
158(2):164-5.
PMID: 15993553
No abstract available.
8.
Vlckova M, Kuban V, Vicar J, Simanek V
Electrophoresis
. 2005 Apr;
26(9):1673-9.
PMID: 15812846
Capillary zone electrophoresis was applied for the investigation of interactions of some quaternary isoquinoline alkaloids, namely sanguinarine, chelerythrine, berberine, and jatrorrhizine, with DNA constituents and with DNA. None of these...
9.
Adamkova H, Vicar J, Palasova J, Ulrichova J, Simanek V
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
. 2004 Nov;
148(1):103-5.
PMID: 15523557
A double-blind, placebo-controlled clinical trial was performed to investigate the effectiveness of a herbal-based dentifrice in the control of gingivitis. Forty volunteers completed the 84-day study. All subjects were balanced...
10.
Psotova J, Lasovsky J, Vicar J
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
. 2004 Mar;
147(2):147-53.
PMID: 15037895
Chelation, electrochemical, antioxidant and cytoprotective properties of six phenolics - cynarin and caffeic, chlorogenic, ferulic, protocatechuic and rosmarinic acids were studied on the following models: (i) chelation of transition metals,...