Jari Koistinaho
Overview
Explore the profile of Jari Koistinaho including associated specialties, affiliations and a list of published articles.
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164
Citations
7084
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Recent Articles
1.
Takalo M, Jeskanen H, Rolova T, Kervinen I, Hellen M, Heikkinen S, et al.
J Neuroinflammation
. 2025 Mar;
22(1):64.
PMID: 40038760
Background: Phospholipase C gamma 2, proline 522 to arginine (PLCγ2-P522R) is a protective variant that reduces the risk of Alzheimer's disease (AD). Recently, it was shown to mitigate β-amyloid pathology...
2.
Rasanen N, Tiihonen J, Koskuvi M, Trontti K, Cheng L, Hill A, et al.
Schizophrenia (Heidelb)
. 2025 Feb;
11(1):21.
PMID: 39966401
Schizophrenia is a complex developmental disorder whose molecular mechanisms are not fully understood. The developmental course of schizophrenia can be modeled with human induced pluripotent stem cell (hiPSC) -derived brain...
3.
Sonninen T, Peltonen S, Niskanen J, Hamalainen R, Koistinaho J, Lehtonen S
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684585
The blood-brain barrier (BBB) serves as an interface between the bloodstream and the central nervous system. It limits the movement of molecules and immune cells, regulates the entry of nutrients,...
4.
Peltonen S, Sonninen T, Niskanen J, Koistinaho J, Ruponen M, Lehtonen S
Fluids Barriers CNS
. 2024 Nov;
21(1):92.
PMID: 39551752
Background: Pericytes play a crucial role in controlling inflammation and vascular functions in the central nervous system, which are disrupted in Parkinson's disease (PD). Still, there is a lack of...
5.
Majernikova N, Marmolejo-Garza A, Salinas C, Luu M, Zhang Y, Trombetta-Lima M, et al.
Cell Death Dis
. 2024 Oct;
15(10):782.
PMID: 39468028
Alzheimer's disease (AD) affects millions of people worldwide and represents the most prevalent form of dementia. Treatment strategies aiming to interfere with the formation of amyloid β (Aβ) plaques and...
6.
Niskanen J, Peltonen S, Ohtonen S, Fazaludeen M, Luk K, Giudice L, et al.
Glia
. 2024 Oct;
73(1):159-174.
PMID: 39435593
Microglia are brain resident immune cells that maintain proteostasis and cellular homeostasis. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson's disease (PD). One of the...
7.
Wu Y, Lehtonen S, Trontti K, Kauppinen R, Kettunen P, Leinonen V, et al.
Fluids Barriers CNS
. 2024 Sep;
21(1):78.
PMID: 39334385
Background: Patients with Alzheimer's disease (AD) frequently present with cerebral amyloid angiopathy (CAA), characterized by the accumulation of beta-amyloid (Aβ) within the cerebral blood vessels, leading to cerebrovascular dysfunction. Pericytes,...
8.
Keuters M, Keksa-Goldsteine V, Rolova T, Jaronen M, Kettunen P, Halkoluoto A, et al.
Sci Rep
. 2024 Aug;
14(1):17949.
PMID: 39095453
Stroke is a leading cause of permanent disability worldwide. Despite intensive research over the last decades, key anti-inflammatory strategies that have proven beneficial in pre-clinical animal models have often failed...
9.
Antila S, Chilov D, Nurmi H, Li Z, Nasi A, Gotkiewicz M, et al.
Nat Cardiovasc Res
. 2024 Aug;
3:474-491.
PMID: 39087029
Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C expression, has raised interest in their...
10.
Naumenko N, Koivumaki J, Lunko O, Tuomainen T, Leigh R, Rabiee M, et al.
J Mol Cell Cardiol
. 2024 Jun;
193:78-87.
PMID: 38851626
Mutations in ubiquitously expressed presenilin genes (PSENs) lead to early-onset familial Alzheimer's disease (FAD), but patients carrying the mutation also suffer from heart diseases. To elucidate the cardiac myocyte specific...