Gundars Goldsteins
Overview
Explore the profile of Gundars Goldsteins including associated specialties, affiliations and a list of published articles.
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46
Citations
1438
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Recent Articles
1.
Niskanen J, Peltonen S, Ohtonen S, Fazaludeen M, Luk K, Giudice L, et al.
Glia
. 2024 Oct;
73(1):159-174.
PMID: 39435593
Microglia are brain resident immune cells that maintain proteostasis and cellular homeostasis. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson's disease (PD). One of the...
2.
Keuters M, Keksa-Goldsteine V, Rolova T, Jaronen M, Kettunen P, Halkoluoto A, et al.
Sci Rep
. 2024 Aug;
14(1):17949.
PMID: 39095453
Stroke is a leading cause of permanent disability worldwide. Despite intensive research over the last decades, key anti-inflammatory strategies that have proven beneficial in pre-clinical animal models have often failed...
3.
Lampinen R, Belaya I, Saveleva L, Liddell J, Rait D, Huuskonen M, et al.
Neurobiol Dis
. 2022 May;
170:105753.
PMID: 35569719
Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether...
4.
Goldsteins G, Hakosalo V, Jaronen M, Keuters M, Lehtonen S, Koistinaho J
Antioxidants (Basel)
. 2022 Feb;
11(2).
PMID: 35204286
A single paragraph of about 200 words maximum. Neurodegenerative diseases (ND), such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, pose a global challenge in the aging population due...
5.
Keuters M, Keksa-Goldsteine V, Dhungana H, Huuskonen M, Pomeshchik Y, Savchenko E, et al.
Sci Rep
. 2021 Feb;
11(1):3518.
PMID: 33568697
Lipid peroxidation-initiated ferroptosis is an iron-dependent mechanism of programmed cell death taking place in neurological diseases. Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone...
6.
Rolova T, Lehtonen S, Goldsteins G, Kettunen P, Koistinaho J
Stem Cells
. 2020 Dec;
39(3):256-265.
PMID: 33270954
The research on neurodegenerative disorders has long focused on neuronal pathology and used transgenic mice as disease models. However, our understanding of the chronic neurodegenerative process in the human brain...
7.
Sonninen T, Goldsteins G, Laham-Karam N, Koistinaho J, Lehtonen S
Cells
. 2020 Oct;
9(10).
PMID: 32998318
Protein homeostasis (proteostasis) disturbances and inflammation are evident in normal aging and some age-related neurodegenerative diseases. While the proteostasis network maintains the integrity of intracellular and extracellular functional proteins, inflammation...
8.
Sonninen T, Hamalainen R, Koskuvi M, Oksanen M, Shakirzyanova A, Wojciechowski S, et al.
Sci Rep
. 2020 Sep;
10(1):14474.
PMID: 32879386
In Parkinson`s disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta is associated with Lewy bodies arising from the accumulation of alpha-synuclein protein which leads...
9.
Kolosowska N, Keuters M, Wojciechowski S, Keksa-Goldsteine V, Laine M, Malm T, et al.
Neurotherapeutics
. 2019 Aug;
16(4):1304-1319.
PMID: 31372938
Neuroinflammation is strongly induced by cerebral ischemia. The early phase after the onset of ischemic stroke is characterized by acute neuronal injury, microglial activation, and subsequent infiltration of blood-derived inflammatory...
10.
Lehtonen S, Sonninen T, Wojciechowski S, Goldsteins G, Koistinaho J
Front Neurosci
. 2019 May;
13:457.
PMID: 31133790
Despite decades of research, current therapeutic interventions for Parkinson's disease (PD) are insufficient as they fail to modify disease progression by ameliorating the underlying pathology. Cellular proteostasis (protein homeostasis) is...