Jared D Hoffman
Overview
Explore the profile of Jared D Hoffman including associated specialties, affiliations and a list of published articles.
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10
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354
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Recent Articles
1.
Yanckello L, Hoffman J, Chang Y, Lin P, Nehra G, Chlipala G, et al.
Nutr Neurosci
. 2021 Mar;
25(8):1669-1679.
PMID: 33666538
Objective: The goal of the study was to identify the potential nutrigenetic effects to inulin, a prebiotic fiber, in mice with different human apolipoprotein E (APOE) genetic variants. Specifically, we...
2.
Hoffman J, Yanckello L, Chlipala G, Hammond T, McCulloch S, Parikh I, et al.
PLoS One
. 2019 Aug;
14(8):e0221828.
PMID: 31461505
The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that...
3.
Caloric Restriction Alters Postprandial Responses of Essential Brain Metabolites in Young Adult Mice
Yanckello L, Young L, Hoffman J, Mohney R, Keaton M, Abner E, et al.
Front Nutr
. 2019 Jun;
6:90.
PMID: 31249833
Caloric restriction (CR) has been shown to extend longevity and protect brain function in aging. However, the effects of CR in young adult mice remain largely unexplored. In addition to...
4.
Lee J, Yanckello L, Ma D, Hoffman J, Parikh I, Thalman S, et al.
Front Aging Neurosci
. 2018 Aug;
10:225.
PMID: 30140223
The mechanistic target of rapamycin (mTOR) is a nutrient sensor of eukaryotic cells. Inhibition of mechanistic mTOR signaling can increase life and health span in various species via interventions that...
5.
Ma D, Wang A, Parikh I, Green S, Hoffman J, Chlipala G, et al.
Sci Rep
. 2018 Apr;
8(1):6670.
PMID: 29703936
Neurovascular integrity, including cerebral blood flow (CBF) and blood-brain barrier (BBB) function, plays a major role in determining cognitive capability. Recent studies suggest that neurovascular integrity could be regulated by...
6.
Hoffman J, Parikh I, Green S, Chlipala G, Mohney R, Keaton M, et al.
Front Aging Neurosci
. 2017 Oct;
9:298.
PMID: 28993728
Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer's disease (AD). However, the contribution of aging processes to AD etiology remains unclear. Emerging evidence...
7.
Lin A, Parikh I, Hoffman J, Ma D
Curr Nutr Rep
. 2017 Oct;
6(1):41-48.
PMID: 28966881
Purpose Of Review: Non-invasive neuroimaging methods have been developed as powerful tools for identifying o brain functions for studies in humans and animals. Here we review the imaging biomarkers that...
8.
Parikh I, Guo J, Chuang K, Zhong Y, Rempe R, Hoffman J, et al.
Aging (Albany NY)
. 2016 Nov;
8(11):2814-2826.
PMID: 27829242
Neurovascular integrity plays an important role in protecting cognitive and mental health in aging. Lifestyle interventions that sustain neurovascular integrity may thus be critical on preserving brain functions in aging...
9.
Ward W, Hoffman J, Loo G
Toxicol Appl Pharmacol
. 2015 Mar;
286(1):17-26.
PMID: 25817893
It is known that ethacrynic acid (EA) decreases the intracellular levels of glutathione. Whether the anticipated oxidative stress affects the structural integrity of DNA is unknown. Therefore, DNA damage was...
10.
Hoffman J, Ward W, Loo G
Mutagenesis
. 2015 Feb;
30(3):421-30.
PMID: 25681790
Isothiocyanates are plant-derived compounds that may be beneficial in the prevention of certain chronic diseases. Yet, by stimulating the production of reactive oxygen species (ROS), isothiocyanates can be genotoxic. Whether...