Ishita Parikh
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Explore the profile of Ishita Parikh including associated specialties, affiliations and a list of published articles.
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14
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738
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Recent Articles
1.
Zajac D, Simpson J, Zhang E, Parikh I, Estus S
Genes (Basel)
. 2023 Mar;
14(3).
PMID: 36981033
The single nucleotide polymorphisms rs35349669 and rs10933431 within Inositol Polyphosphate-5-Phosphatase D () are strongly associated with Alzheimer's Disease risk. To better understand expression in the brain, we investigated isoform expression...
2.
Lin A, Parikh I, Yanckello L, White R, Hartz A, Taylor C, et al.
Neurobiol Dis
. 2020 Mar;
139:104834.
PMID: 32173556
The ε4 allele of Apolipoprotein (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), the most common form of dementia. Cognitively normal APOE4 carriers have developed amyloid beta...
3.
Maldonado Weng J, Parikh I, Naqib A, York J, Green S, Estus S, et al.
Mol Neurodegener
. 2019 Dec;
14(1):47.
PMID: 31861986
Background: Alzheimer's disease (AD) is a fatal neurodegenerative disease. APOE4 is the greatest genetic risk factor for AD, increasing risk up to 15-fold compared to the common APOE3. Importantly, female...
4.
Hoffman J, Yanckello L, Chlipala G, Hammond T, McCulloch S, Parikh I, et al.
PLoS One
. 2019 Aug;
14(8):e0221828.
PMID: 31461505
The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that...
5.
Lee J, Yanckello L, Ma D, Hoffman J, Parikh I, Thalman S, et al.
Front Aging Neurosci
. 2018 Aug;
10:225.
PMID: 30140223
The mechanistic target of rapamycin (mTOR) is a nutrient sensor of eukaryotic cells. Inhibition of mechanistic mTOR signaling can increase life and health span in various species via interventions that...
6.
Ma D, Wang A, Parikh I, Green S, Hoffman J, Chlipala G, et al.
Sci Rep
. 2018 Apr;
8(1):6670.
PMID: 29703936
Neurovascular integrity, including cerebral blood flow (CBF) and blood-brain barrier (BBB) function, plays a major role in determining cognitive capability. Recent studies suggest that neurovascular integrity could be regulated by...
7.
Hoffman J, Parikh I, Green S, Chlipala G, Mohney R, Keaton M, et al.
Front Aging Neurosci
. 2017 Oct;
9:298.
PMID: 28993728
Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer's disease (AD). However, the contribution of aging processes to AD etiology remains unclear. Emerging evidence...
8.
Lin A, Parikh I, Hoffman J, Ma D
Curr Nutr Rep
. 2017 Oct;
6(1):41-48.
PMID: 28966881
Purpose Of Review: Non-invasive neuroimaging methods have been developed as powerful tools for identifying o brain functions for studies in humans and animals. Here we review the imaging biomarkers that...
9.
Parikh I, Guo J, Chuang K, Zhong Y, Rempe R, Hoffman J, et al.
Aging (Albany NY)
. 2016 Nov;
8(11):2814-2826.
PMID: 27829242
Neurovascular integrity plays an important role in protecting cognitive and mental health in aging. Lifestyle interventions that sustain neurovascular integrity may thus be critical on preserving brain functions in aging...
10.
Malik M, Parikh I, Vasquez J, Smith C, Tai L, Bu G, et al.
Mol Neurodegener
. 2015 Oct;
10:52.
PMID: 26438529
In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the...