Jared Cumming
Overview
Explore the profile of Jared Cumming including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
67
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Recent Articles
1.
Perera S, Kopinja J, Ma Y, Muise E, Laskey J, Chakravarthy K, et al.
Mol Cancer Ther
. 2021 Nov;
21(2):282-293.
PMID: 34815361
The innate immune agonist STING (STimulator of INterferon Genes) binds its natural ligand 2'3'-cGAMP (cyclic guanosine-adenosine monophosphate) and initiates type I IFN production. This promotes systemic antigen-specific CD8 T-cell priming...
2.
Li D, Zhang H, Lyons T, Lu M, Achab A, Pu Q, et al.
ACS Med Chem Lett
. 2021 Nov;
12(11):1678-1688.
PMID: 34795856
Comprehensive synthetic strategies afforded a diverse set of structurally unique bicyclic proline-containing arginase inhibitors with a high degree of three-dimensionality. The analogs that favored the Cγ-exo conformation of the proline...
3.
Lu M, Zhang H, Li D, Childers M, Pu Q, Palte R, et al.
ACS Med Chem Lett
. 2021 Sep;
12(9):1380-1388.
PMID: 34527178
Recent data suggest that the inhibition of arginase (ARG) has therapeutic potential for the treatment of a number of indications ranging from pulmonary and vascular disease to cancer. Thus, high...
4.
Sheridan R, Zorn N, Sherer E, Campeau L, Chang C, Cumming J, et al.
J Chem Inf Model
. 2014 May;
54(6):1604-16.
PMID: 24802889
This paper brings together the concepts of molecular complexity and crowdsourcing. An exercise was done at Merck where 386 chemists voted on the molecular complexity (on a scale of 1-5)...
5.
Cumming J, Babu S, Huang Y, Carrol C, Chen X, Favreau L, et al.
Bioorg Med Chem Lett
. 2010 Mar;
20(9):2837-42.
PMID: 20347593
With collaboration between chemistry, X-ray crystallography, and molecular modeling, we designed and synthesized a series of novel piperazine sulfonamide BACE1 inhibitors. Iterative exploration of the non-prime side and S2' sub-pocket...
6.
Zhu Z, Sun Z, Ye Y, Voigt J, Strickland C, Smith E, et al.
J Med Chem
. 2010 Jan;
53(3):951-65.
PMID: 20043696
A number of novel amidine containing heterocycles were designed to reproduce the unique interaction pattern, revealed by X-ray crystallography, between the BACE-1 catalytic diad and a weak NMR screening hit...