Jared A Delmar
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Explore the profile of Jared A Delmar including associated specialties, affiliations and a list of published articles.
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21
Citations
430
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Recent Articles
1.
Mechanism of Insoluble Aggregate Formation in a Reconstituted Solution of Spray-Dried Protein Powder
Tao Y, Chen Y, Howard W, Ibrahim M, Patel S, McMahon W, et al.
Pharm Res
. 2023 May;
40(10):2355-2370.
PMID: 37131104
Background: Spray-drying is considered a promising alternative drying method to lyophilization (freeze-drying) for therapeutic proteins. Particle counts in reconstituted solutions of dried solid dosage forms of biologic drug products are...
2.
Delmar J, Harris C, Grassi L, Macapagal N, Wang J, Hatton D, et al.
J Pharm Sci
. 2022 Aug;
111(11):3009-3016.
PMID: 35940243
During early stage development of a therapeutic IgG1 monoclonal antibody, high levels of low molecular weight (LMW) peaks were observed by high performance size-exclusion chromatography and capillary electrophoresis. Further characterization...
3.
Chaerkady R, Zhou Y, Delmar J, Weng S, Wang J, Awasthi S, et al.
J Proteome Res
. 2021 May;
20(6):3150-3164.
PMID: 34008986
Citrullination is an important post-translational modification implicated in many diseases including rheumatoid arthritis (RA), Alzheimer's disease, and cancer. Neutrophil and mast cells have different expression profiles for protein-arginine deiminases (PADs),...
4.
Delmar J, Buehler E, Chetty A, Das A, Quesada G, Wang J, et al.
Mol Ther Methods Clin Dev
. 2021 Apr;
21:466-477.
PMID: 33898635
Photooxidation of methionine (Met) and tryptophan (Trp) residues is common and includes major degradation pathways that often pose a serious threat to the success of therapeutic proteins. Oxidation impacts all...
5.
Erratum: Machine Learning Enables Accurate Prediction of Asparagine Deamidation Probability and Rate
Delmar J, Wang J, Choi S, Martins J, Mikhail J
Mol Ther Methods Clin Dev
. 2020 Nov;
19:374.
PMID: 33145373
[This corrects the article DOI: 10.1016/j.omtm.2019.09.008.].
6.
Delmar J, Wang J, Choi S, Martins J, Mikhail J
Mol Ther Methods Clin Dev
. 2020 Jan;
15:264-274.
PMID: 31890727
The spontaneous conversion of asparagine residues to aspartic acid or iso-aspartic acid, via deamidation, is a major pathway of protein degradation and is often seriously disruptive to biological systems. Deamidation...
7.
Delmar J, Yu E
Methods Mol Biol
. 2017 Nov;
1700:59-70.
PMID: 29177825
Crystallization is one of the most successful techniques used to determine protein structure, especially for membrane proteins. However, the application of this technique is not straightforward and often hampered by...
8.
Su C, Yin L, Kumar N, Dai L, Radhakrishnan A, Bolla J, et al.
Nat Commun
. 2017 Aug;
8(1):171.
PMID: 28761097
Resistance-nodulation-cell division efflux pumps are integral membrane proteins that catalyze the export of substrates across cell membranes. Within the hydrophobe-amphiphile efflux subfamily, these resistance-nodulation-cell division proteins largely form trimeric efflux...
9.
Kumar N, Su C, Chou T, Radhakrishnan A, Delmar J, Rajashankar K, et al.
Proc Natl Acad Sci U S A
. 2017 Jun;
114(25):6557-6562.
PMID: 28584102
Strains of the complex (Bcc) are Gram-negative opportunisitic bacteria that are capable of causing serious diseases, mainly in immunocompromised individuals. Bcc pathogens are intrinsically resistant to multiple antibiotics, including β-lactams,...
10.
Delmar J, Yu E
Protein Sci
. 2015 Oct;
25(2):322-37.
PMID: 26443496
The AbgT family of transporters was thought to contribute to bacterial folate biosynthesis by importing the catabolite p-aminobenzoyl-glutamate for producing this essential vitamin. Approximately 13,000 putative transporters of the family...