Januka Khanal
Overview
Explore the profile of Januka Khanal including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
257
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0
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Recent Articles
1.
Shi D, Lee J, Wang A, Khanal J, Gao W, Kaelin Jr W, et al.
STAR Protoc
. 2023 May;
4(2):102281.
PMID: 37149859
Lower-grade gliomas exhibit a high prevalence of isocitrate dehydrogenase 1 (IDH1) mutations, but faithful models for studying these tumors are lacking. Here, we present a protocol to establish a genetically...
2.
Shi D, Savani M, Levitt M, Wang A, Endress J, Bird C, et al.
Cancer Cell
. 2022 Aug;
40(9):939-956.e16.
PMID: 35985343
Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia, they seem to be less active in aggressive...
3.
McBrayer S, Mayers J, DiNatale G, Shi D, Khanal J, Chakraborty A, et al.
Cell
. 2018 Sep;
175(1):101-116.e25.
PMID: 30220459
IDH1 mutations are common in low-grade gliomas and secondary glioblastomas and cause overproduction of (R)-2HG. (R)-2HG modulates the activity of many enzymes, including some that are linked to transformation and...
4.
McBrayer S, Olenchock B, DiNatale G, Shi D, Khanal J, Jennings R, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(16):E3741-E3748.
PMID: 29610306
Inactivation of the retinoblastoma gene () product, pRB, is common in many human cancers. Targeting downstream effectors of pRB that are central to tumorigenesis is a promising strategy to block...
5.
Shockett P, Khanal J, Sitaula A, Oglesby C, Meachum W, Castracane V, et al.
Physiol Rep
. 2016 Jan;
4(1).
PMID: 26755735
Increased plasma cell-free mitochondrial DNA (cf-mDNA), a damage-associated molecular pattern (DAMP) produced by cellular injury, contributes to neutrophil activation/inflammation in trauma patients and arises in cancer and autoimmunity. To further...