Samuel K McBrayer
Overview
Explore the profile of Samuel K McBrayer including associated specialties, affiliations and a list of published articles.
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46
Citations
1511
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Recent Articles
1.
Lanman T, Youssef G, Huang R, Rahman R, DeSalvo M, Flood T, et al.
Neurooncol Adv
. 2025 Feb;
7(1):vdae227.
PMID: 39911703
Background: Mutant isocitrate dehydrogenase (IDHm) inhibitors represent a novel targeted approach for treating IDHm glioma patients, yet their optimal use in clinical practice outside of clinical trials remains undefined. This...
2.
Nair R, Vu A, Vu A, Freer A, Bhatia K, Wang D, et al.
Blood
. 2024 Dec;
145(7):732-747.
PMID: 39693611
We previously demonstrated that reduced intrinsic electron transport chain (ETC) activity predicts and promotes sensitivity to the B-cell lymphoma 2 (BCL-2) antagonist, venetoclax (Ven), in multiple myeloma (MM). Heme, an...
3.
Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
Liu R, Ren X, Park Y, Feng H, Sheng X, Song X, et al.
Cell Metab
. 2024 Dec;
37(2):377-394.e9.
PMID: 39642882
Histone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate...
4.
Hicks W, Gattie L, Shami M, Traylor J, Davar D, Najjar Y, et al.
Sci Rep
. 2024 Oct;
14(1):24843.
PMID: 39438602
Despite advances in the treatment paradigm for patients with metastatic melanoma, melanoma brain metastasis (MBM) continues to represent a significant treatment challenge. The study of MBM is limited, in part,...
5.
Lin M, Tsai A, Abdullah K, McBrayer S, Shi D
NPJ Precis Oncol
. 2024 Jul;
8(1):149.
PMID: 39025958
Gliomas are the most common primary brain tumor and are uniformly lethal. Despite significant advancements in understanding the genetic landscape of gliomas, standard-of-care has remained largely unchanged. Subsets of gliomas...
6.
Richardson T, Walker J, Hambardzumyan D, Brem S, Hatanpaa K, Viapiano M, et al.
Acta Neuropathol
. 2024 Jul;
148(1):5.
PMID: 39012509
In recent years, the classification of adult-type diffuse gliomas has undergone a revolution, wherein specific molecular features now represent defining diagnostic criteria of IDH-wild-type glioblastomas, IDH-mutant astrocytomas, and IDH-mutant 1p/19q-codeleted...
7.
Wu M, Kondo H, Kammula A, Shi L, Xiao Y, Dhiab S, et al.
Science
. 2024 Jul;
385(6705):eadl6173.
PMID: 38991060
() is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A hallmark of -mutant...
8.
Hicks W, Gattie L, Traylor J, Davar D, Najjar Y, Richardson DO T, et al.
bioRxiv
. 2024 Feb;
PMID: 38328251
Purpose: Despite significant advances in the treatment paradigm for patients with metastatic melanoma, melanoma brain metastasis (MBM) continues to represent a significant treatment challenge. The study of MBM is limited,...
9.
Richardson T, Yokoda R, Rashidipour O, Vij M, Snuderl M, Brem S, et al.
Neurooncol Adv
. 2023 Aug;
5(1):vdad085.
PMID: 37554222
Background: Mutations in mismatch repair (MMR) genes (, , , and are associated with microsatellite instability and a hypermutator phenotype in numerous systemic cancers, and germline MMR mutations have been...
10.
Shami M, Savani M, Gattie L, Smith B, Hicks W, Rich J, et al.
bioRxiv
. 2023 Jul;
PMID: 37398280
Purpose: Metabolism within the tumor microenvironment (TME) represents an increasing area of interest to understand glioma initiation and progression. Stable isotope tracing is a technique critical to the study of...