Janni Nielsen
Overview
Explore the profile of Janni Nielsen including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
112
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Recent Articles
1.
Singh P, Kadam N, Panigrahi R, Mehrotra A, Upadhayay K, Dey M, et al.
ACS Chem Neurosci
. 2025 Feb;
16(5):880-894.
PMID: 39936279
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. The presence of Lewy bodies, primarily consisting of amyloid aggregates of the protein α-synuclein (α-Syn), is a common feature seen...
2.
Shiraz M, Nielsen J, Widmann J, Karen Chung K, Davis T, Rasmussen C, et al.
Mol Cells
. 2024 Nov;
48(1):100161.
PMID: 39603509
The clinical manifestations of Parkinson's disease (PD) are driven by aggregation of α-Synuclein (α-Syn) in the brain. However, there is increasing evidence that PD may be initiated in the gut...
3.
Nielsen J, Lauritsen J, Pedersen J, Nowak J, Bendtsen M, Kleijwegt G, et al.
NPJ Parkinsons Dis
. 2024 Jul;
10(1):139.
PMID: 39075088
α-Synuclein (α-syn) accumulates as insoluble amyloid but also forms soluble α-syn oligomers (αSOs), thought to be even more cytotoxic than fibrils. To detect and block the unwanted activities of these...
4.
Adam L, Kumar R, Arroyo-Garcia L, Molenkamp W, Nowak J, Klute H, et al.
Protein Sci
. 2024 Jul;
33(8):e5091.
PMID: 38980078
Protein misfolding and aggregation are involved in several neurodegenerative disorders, such as α-synuclein (αSyn) implicated in Parkinson's disease, where new therapeutic approaches remain essential to combat these devastating diseases. Elucidating...
5.
Roeters S, Strunge K, Pedersen K, Golbek T, Bregnhoj M, Zhang Y, et al.
Nat Commun
. 2023 Sep;
14(1):5731.
PMID: 37723164
The amyloid aggregation of α-synuclein (αS), related to Parkinson's disease, can be catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and orientation of lipid-bound αS is...
6.
Andersen C, Lausdahl A, Nielsen J, Clausen M, Mulder F, Otzen D, et al.
Biochemistry
. 2023 Jul;
62(16):2417-2425.
PMID: 37487228
Oxidative stress and formation of cytotoxic oligomers by the natively unfolded protein α-synuclein (α-syn) are both connected to the development of Parkinson's disease. This effect has been linked to lipid...
7.
Rasmussen H, Nielsen J, de Poli A, Otzen D, Pedersen J
J Mol Biol
. 2023 Jul;
435(17):168194.
PMID: 37437877
The protein tau is involved in several neurogenerative diseases such as Alzheimer's Disease, where tau content and fibrillation have been linked to disease progression. Tau colocalizes with phospholipids and glycosaminoglycans...
8.
Evans D, Khamas A, Marcussen L, Rasmussen K, Klitgaard J, Kallipolitis B, et al.
Microb Cell
. 2023 Jul;
10(7):145-156.
PMID: 37395997
is a major human pathogen that utilises many surface-associated and secreted proteins to form biofilms and cause disease. However, our understanding of these processes is limited by challenges of using...
9.
Najarzadeh Z, Mohammad-Beigi H, Pedersen J, Christiansen G, Pedersen J, Nielsen J, et al.
BBA Adv
. 2023 Apr;
2:100055.
PMID: 37082589
Functional amyloids (FA) are proteins which are evolutionarily optimized to form highly stable fibrillar structures that strengthen the bacterial biofilm matrix. FA such as CsgA () and FapC () are...
10.
Somavarapu A, Kleijwegt G, Nagaraj M, Alam P, Nielsen J, Otzen D
Chem Sci
. 2023 Mar;
14(11):3030-3047.
PMID: 36937574
Small soluble oligomers of the protein α-synuclein (αSO) have been linked to disruptions in neuronal homeostasis, contributing to the development of Parkinson's Disease (PD). While this makes αSO an obvious...