Janet van Eersel
Overview
Explore the profile of Janet van Eersel including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
25
Citations
1698
Followers
0
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ariawan D, van der Hoven J, Morey N, Pushpitha K, Genoud S, Stefen H, et al.
J Med Chem
. 2024 Dec;
68(5):5211-5221.
PMID: 39630561
Cyclotides are naturally occurring cyclic peptides with three disulfide bonds, offering remarkable stability. In neurological disorders, the formation of a complex between postsynaptic density protein 95 and NMDA receptors (NMDARs)...
2.
Ariawan D, Thananthirige K, El-Omar A, van der Hoven J, Genoud S, Stefen H, et al.
RSC Adv
. 2024 Oct;
14(47):34637-34642.
PMID: 39479480
Peptide therapeutics are an emerging class of drugs to treat neurodegenerative diseases by inhibiting protein-protein interactions (PPIs). Nerinetide has recently emerged as a promising therapeutic for the treatment of ischemic...
3.
Morey N, Przybyla M, van der Hoven J, Ke Y, Delerue F, van Eersel J, et al.
Sci Adv
. 2022 Dec;
8(48):eadd2577.
PMID: 36459557
Hyperphosphorylated microtubule-associated protein tau has been implicated in dementia, epilepsy, and other neurological disorders. In contrast, site-specific phosphorylation of tau at threonine 205 (T205) by the kinase p38γ was shown...
4.
Ariawan D, van Eersel J, Martin A, Ke Y, Ittner L
Biomater Sci
. 2022 Jun;
10(15):4037-4057.
PMID: 35708540
Vaccination is a proven way to protect individuals against many infectious diseases, as currently highlighted in the global COVID-19 pandemic. Peptides- or small molecule antigen-based vaccination offer advantages over the...
5.
Ariawan D, Au C, Paric E, Fath T, Ke Y, Kassiou M, et al.
Front Chem
. 2021 Dec;
9:781213.
PMID: 34966720
The LIM-domain kinase (LIMK) family consists of two isoforms, LIMK1 and LIMK2, which are highly homologous, making selective inhibitor development challenging. LIMK regulates dynamics of the actin cytoskeleton, thereby impacting...
6.
van der Hoven J, van Hummel A, Przybyla M, Asih P, Gajwani M, Feiten A, et al.
Sci Rep
. 2020 Aug;
10(1):13845.
PMID: 32796905
Antibodies have been explored extensively as a potential therapeutic for Alzheimer's disease, where amyloid-β (Aβ) peptides and the tau protein deposit in patient brains. While the major focus of antibody-based...
7.
Przybyla M, van Eersel J, van Hummel A, van der Hoven J, Sabale M, Harasta A, et al.
Brain
. 2020 May;
143(6):1889-1904.
PMID: 32375177
Hyperphosphorylation and deposition of tau in the brain characterizes frontotemporal dementia and Alzheimer's disease. Disease-associated mutations in the tau-encoding MAPT gene have enabled the generation of transgenic mouse models that...
8.
Watt G, Przybyla M, Zak V, van Eersel J, Ittner A, Ittner L, et al.
Neuroscience
. 2020 Feb;
431:166-175.
PMID: 32058066
Alzheimer's disease (AD) is a neurodegenerative disease characterised by progressive cognitive decline and the accumulation of two hallmark proteins, amyloid-beta (Aβ) and tau. Traditionally, transgenic mouse models for AD have...
9.
Lei M, Teo J, Song H, McEwen H, Lee J, Couttas T, et al.
J Neurosci
. 2019 Oct;
39(48):9645-9659.
PMID: 31641049
Sphingosine 1-phosphate (S1P) is a potent vasculoprotective and neuroprotective signaling lipid, synthesized primarily by sphingosine kinase 2 (SK2) in the brain. We have reported pronounced loss of S1P and SK2...
10.
Bi M, Gladbach A, van Eersel J, Ittner A, Przybyla M, van Hummel A, et al.
Nat Commun
. 2017 Sep;
8(1):473.
PMID: 28883427
Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here we show that tau-deficient (tau) mice are profoundly protected from excitotoxic brain damage and...