Janet van Eersel
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Explore the profile of Janet van Eersel including associated specialties, affiliations and a list of published articles.
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25
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1698
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Recent Articles
11.
Ahmed R, Irish M, van Eersel J, Ittner A, Ke Y, Volkerling A, et al.
Neurosci Biobehav Rev
. 2017 Jan;
74(Pt A):126-138.
PMID: 28088537
Frontotemporal dementia (FTD) is the second most common cause of young onset dementia. It is increasingly recognized that there is a clinical continuum between FTD and amyotrophic lateral sclerosis (ALS)....
12.
Chua S, Cornejo A, van Eersel J, Stevens C, Vaca I, Cueto M, et al.
ACS Chem Neurosci
. 2017 Jan;
8(4):743-751.
PMID: 28067492
In Alzheimer's disease, the microtubule-associated protein tau forms intracellular neurofibrillary tangles (NFTs). A critical step in the formation of NFTs is the conversion of soluble tau into insoluble filaments. Accordingly,...
13.
Przybyla M, Stevens C, van der Hoven J, Harasta A, Bi M, Ittner A, et al.
Neurosci Lett
. 2016 Aug;
631:24-29.
PMID: 27521751
Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models...
14.
van Eersel J, Stevens C, Przybyla M, Gladbach A, Stefanoska K, Chan C, et al.
Neuropathol Appl Neurobiol
. 2015 Mar;
41(7):906-25.
PMID: 25763777
Aim: Tau becomes hyperphosphorylated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-tau), resulting in functional deficits of neurones, neurofibrillary tangle (NFT) formation and eventually dementia. Expression of mutant human...
15.
Purushothuman S, Johnstone D, Nandasena C, van Eersel J, Ittner L, Mitrofanis J, et al.
Neurosci Lett
. 2015 Feb;
591:155-159.
PMID: 25703226
We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigated by near infrared light (NIr). Here, we extend these observations to...
16.
Ittner A, Bertz J, Chan T, van Eersel J, Polly P, Ittner L
Diabetologia
. 2014 Apr;
57(7):1410-9.
PMID: 24733160
Aims/hypothesis: Regulation of insulin secretion along the secretory pathway is incompletely understood. We addressed the expression of SIL1, a nucleotide exchange factor for the endoplasmic reticulum (ER) chaperone glucose-regulated protein...
17.
Gladbach A, van Eersel J, Bi M, Ke Y, Ittner L
J Neural Transm (Vienna)
. 2013 Dec;
121(5):543-7.
PMID: 24337667
Ischemic stroke is a leading cause of death. It has previously been shown that blocking activation of extracellular signal-regulated kinase (ERK) with the MEK inhibitor U0126 mitigates brain damage in...
18.
Ke Y, Suchowerska A, van der Hoven J, De Silva D, Wu C, van Eersel J, et al.
Int J Alzheimers Dis
. 2012 Jun;
2012:873270.
PMID: 22720190
Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. This unifying pathology led to...
19.
van Eersel J, Ke Y, Gladbach A, Bi M, Gotz J, Kril J, et al.
PLoS One
. 2011 Aug;
6(7):e22850.
PMID: 21829535
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by intraneuronal deposition of the nuclear TAR DNA-binding protein 43 (TDP-43) caused by unknown mechanisms. Here, we studied TDP-43...
20.
Ittner A, Ke Y, van Eersel J, Gladbach A, Gotz J, Ittner L
IUBMB Life
. 2011 Jun;
63(7):495-502.
PMID: 21698753
Both Alzheimer's disease (AD) and almost every second case of frontotemporal lobar degeneration (FTLD) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or...