Janet J Maguire
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Explore the profile of Janet J Maguire including associated specialties, affiliations and a list of published articles.
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79
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2408
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Recent Articles
1.
Williams T, Verdon G, Kuc R, Currinn H, Bender B, Solcan N, et al.
Nat Commun
. 2024 Dec;
15(1):10714.
PMID: 39730334
We describe a structural and functional study of the G protein-coupled apelin receptor, which binds two endogenous peptide ligands, apelin and Elabela/Toddler (ELA), to regulate cardiovascular development and function. Characterisation...
2.
Chapman F, Melville V, Godden E, Morrison B, Bruce L, Maguire J, et al.
Nat Commun
. 2024 Oct;
15(1):8387.
PMID: 39402039
Chronic kidney disease (CKD) affects ~10% of the population and cardiovascular disease is its commonest complication. Despite treatment, patient outcomes remain poor and newer therapies are urgently needed. Here, we...
3.
Abraham G, Williams T, Maguire J, Greasley P, Ambery P, Davenport A
Nat Cardiovasc Res
. 2024 Aug;
2(11):972-990.
PMID: 39196099
The first endothelin (ET)-1 receptor antagonist was approved for clinical use over 20 years ago, but to date this class of compounds has been limited to treating pulmonary arterial hypertension,...
4.
Owen N, Williams T, Maguire J, Kuc R, Davenport E, Davenport A
Biosci Rep
. 2024 Jun;
44(7).
PMID: 38860875
High blood pressure in the portal vein, portal hypertension (PH), is the final common pathway in liver cirrhosis regardless of aetiology. Complications from PH are the major cause of morbidity...
5.
Williams T, Nwokoye P, Kuc R, Smith K, Paterson A, Allinson K, et al.
Front Neurosci
. 2024 May;
18:1379658.
PMID: 38803685
Glioblastoma multiforme (GBM) is one of the most common and lethal forms of brain cancer, carrying a very poor prognosis (median survival of ~15 months post-diagnosis). Treatment typically involves invasive...
6.
Williams T, Kuc R, Paterson A, Abraham G, Pullinger A, Maguire J, et al.
Biosci Rep
. 2024 May;
44(6).
PMID: 38747277
Methods: Immunocytochemistry localised SGLT-2, ETA and ETB receptors in sections of histologically normal kidney, left ventricle from patients undergoing heart transplantation or controls. Primary antisera were visualised using fluorescent microscopy....
7.
Williams T, Nyimanu D, Kuc R, Foster R, Glen R, Maguire J, et al.
Front Pharmacol
. 2024 Apr;
15:1369489.
PMID: 38655187
Pulmonary arterial hypertension (PAH) is characterised by endothelial dysfunction and pathological vascular remodelling, resulting in the occlusion of pulmonary arteries and arterioles, right ventricular hypertrophy, and eventually fatal heart failure....
8.
Chapman F, Maguire J, Newby D, Davenport A, Dhaun N
Cardiovasc Res
. 2023 Nov;
119(17):2683-2696.
PMID: 37956047
Cardiovascular disease is the leading cause of death worldwide. Its prevalence is rising due to ageing populations and the increasing incidence of diseases such as chronic kidney disease, obesity, and...
9.
Williams T, Macrae R, Kuc R, Brown A, Maguire J, Davenport A
Front Endocrinol (Lausanne)
. 2023 Mar;
14:1139121.
PMID: 36967803
Introduction: The apelin receptor binds two distinct endogenous peptides, apelin and ELA, which act in an autocrine/paracrine manner to regulate the human cardiovascular system. As a class A GPCR, targeting...
10.
Abraham G, Nyimanu D, Kuc R, Maguire J, Davenport A, Hoole S
J Interv Cardiol
. 2022 Oct;
2022:9154048.
PMID: 36262459
Objective: Coronary microvascular dysfunction (CMD) can complicate successful percutaneous coronary intervention (PCI). The potent endogenous vasoconstrictor peptide Endothelin-1 (ET-1) may be an important mediator. To investigate the mechanism, we sought...