Jane E Sexton
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Explore the profile of Jane E Sexton including associated specialties, affiliations and a list of published articles.
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10
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198
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Recent Articles
1.
Fuller A, Luiz A, Tian N, Arcangeletti M, Iseppon F, Sexton J, et al.
Brain
. 2023 May;
146(10):4033-4039.
PMID: 37249190
Melzak and Wall's gate control theory proposed that innocuous input into the dorsal horn of the spinal cord represses pain-inducing nociceptive input. Here we show that input from proprioceptive parvalbumin-expressing...
2.
Santana-Varela S, Bogdanov Y, Gossage S, Okorokov A, Li S, de Clauser L, et al.
Wellcome Open Res
. 2022 Mar;
6:250.
PMID: 35233469
Somatosensation depends on primary sensory neurons of the trigeminal and dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has defined at least 18 distinct neuronal cell types....
3.
Bangash M, Alles S, Santana-Varela S, Millet Q, Sikandar S, de Clauser L, et al.
Wellcome Open Res
. 2018 Aug;
3:78.
PMID: 30079380
Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations...
4.
Raouf R, Lolignier S, Sexton J, Millet Q, Santana-Varela S, Biller A, et al.
Sci Signal
. 2018 Jun;
11(535).
PMID: 29921656
Mechanically activated, slowly adapting currents in sensory neurons have been linked to noxious mechanosensation. The conotoxin NMB-1 (noxious mechanosensation blocker-1) blocks such currents and inhibits mechanical pain. Using a biotinylated...
5.
Sexton J, Cox J, Zhao J, Wood J
Annu Rev Pharmacol Toxicol
. 2017 Oct;
58:123-142.
PMID: 28968191
Pain is an increasing clinical challenge affecting about half the population, with a substantial number of people suffering daily intense pain. Such suffering can be linked to the dramatic rise...
6.
Isensee J, Krahe L, Moeller K, Pereira V, Sexton J, Sun X, et al.
Sci Signal
. 2017 Jan;
10(461).
PMID: 28074005
Genetic loss of the voltage-gated sodium channel Na1.7 (Na1.7) results in lifelong insensitivity to pain in mice and humans. One underlying cause is an increase in the production of endogenous...
7.
Sexton J, Desmonds T, Quick K, Taylor R, Abramowitz J, Forge A, et al.
Neurosci Lett
. 2015 Nov;
610:36-42.
PMID: 26520460
Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features...
8.
Sexton J, Vernon J, Wood J
Handb Exp Pharmacol
. 2014 Jun;
223:873-97.
PMID: 24961972
Pain usually occurs as a result of tissue damage and has a role in healing and protection. However, in certain conditions it has no functional purpose and can become chronic...
9.
Quick K, Zhao J, Eijkelkamp N, Linley J, Rugiero F, Cox J, et al.
Open Biol
. 2012 Jun;
2(5):120068.
PMID: 22724068
Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice caused no behavioural phenotype, although...
10.
Becker D, Sexton J, Jacobs L, Hogarty B, Keeley K
Environ Monit Assess
. 2008 Aug;
154(1-4):427-38.
PMID: 18677548
In 2001, 28 acres of the bottom of Ward Cove, AK (USA) were remediated using thin layer placement, to enhance the natural recovery of contaminated sediments. The remediated areas were...