Jana Narasimhan
Overview
Explore the profile of Jana Narasimhan including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
27
Citations
1046
Followers
0
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Recent Articles
11.
Morini E, Gao D, Montgomery C, Salani M, Mazzasette C, Krussig T, et al.
Am J Hum Genet
. 2019 Mar;
104(4):638-650.
PMID: 30905397
Familial dysautonomia (FD) is a recessive neurodegenerative disease caused by a splice mutation in Elongator complex protein 1 (ELP1, also known as IKBKAP); this mutation leads to variable skipping of...
12.
Gerasyuto A, Arnold M, Wang J, Chen G, Zhang X, Smith S, et al.
J Med Chem
. 2018 Oct;
61(20):9394.
PMID: 30351051
No abstract available.
13.
Gerasyuto A, Arnold M, Wang J, Chen G, Zhang X, Smith S, et al.
J Med Chem
. 2018 May;
61(10):4456-4475.
PMID: 29727185
There exists an urgent medical need to identify new chemical entities (NCEs) targeting multidrug resistant (MDR) bacterial infections, particularly those caused by Gram-negative pathogens. 4-Hydroxy-2-pyridones represent a novel class of...
14.
Arnold M, Gerasyuto A, Wang J, Du W, Gorske Y, Arasu T, et al.
Bioorg Med Chem Lett
. 2017 Oct;
27(22):5014-5021.
PMID: 29032026
The continued emergence of bacteria resistant to current standard of care antibiotics presents a rapidly growing threat to public health. New chemical entities (NCEs) to treat these serious infections are...
15.
Woll M, Qi H, Turpoff A, Zhang N, Zhang X, Chen G, et al.
J Med Chem
. 2016 Jun;
59(13):6070-85.
PMID: 27299569
The underlying cause of spinal muscular atrophy (SMA) is a deficiency of the survival motor neuron (SMN) protein. Starting from hits identified in a high-throughput screening campaign and through structure-activity...
16.
Veselkov D, Laponogov I, Pan X, Selvarajah J, Skamrova G, Branstrom A, et al.
Acta Crystallogr D Struct Biol
. 2016 Apr;
72(Pt 4):488-96.
PMID: 27050128
Klebsiella pneumoniae is a Gram-negative bacterium that is responsible for a range of common infections, including pulmonary pneumonia, bloodstream infections and meningitis. Certain strains of Klebsiella have become highly resistant...
17.
Zhao X, Feng Z, Ling K, Mollin A, Sheedy J, Yeh S, et al.
Hum Mol Genet
. 2016 Mar;
25(10):1885-1899.
PMID: 26931466
Spinal muscular atrophy (SMA) is caused by the loss or mutation of both copies of the survival motor neuron 1 (SMN1) gene. The related SMN2 gene is retained, but due...
18.
Naryshkin N, Weetall M, Dakka A, Narasimhan J, Zhao X, Feng Z, et al.
Science
. 2014 Aug;
345(6197):688-93.
PMID: 25104390
Spinal muscular atrophy (SMA) is a genetic disease caused by mutation or deletion of the survival of motor neuron 1 (SMN1) gene. A paralogous gene in humans, SMN2, produces low,...
19.
Utility of survival motor neuron ELISA for spinal muscular atrophy clinical and preclinical analyses
Kobayashi D, Olson R, Sly L, Swanson C, Chung B, Naryshkin N, et al.
PLoS One
. 2011 Sep;
6(8):e24269.
PMID: 21904622
Objectives: Genetic defects leading to the reduction of the survival motor neuron protein (SMN) are a causal factor for Spinal Muscular Atrophy (SMA). While there are a number of therapies...
20.
Zaborske J, Narasimhan J, Jiang L, Wek S, Dittmar K, Freimoser F, et al.
J Biol Chem
. 2009 Jun;
284(37):25254-67.
PMID: 19546227
When cells are subjected to nutritional stress, uncharged tRNAs accumulate and activate Gcn2p phosphorylation of eukaryotic initiation factor-2 (eIF2) and the general amino acid control pathway. The Gcn2p regulatory domain...