Frans van Roy
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Explore the profile of Frans van Roy including associated specialties, affiliations and a list of published articles.
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109
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4349
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Recent Articles
1.
Keeney J, Astling D, Andries V, Vandepoele K, Anderson N, Davis J, et al.
bioRxiv
. 2024 Nov;
PMID: 39484454
Encoded by the NBPF gene family, Olduvai (formerly DUF1220) protein domains have undergone the largest human lineage-specific copy number expansion of any coding region in the genome. Olduvai copy number...
2.
Aerts T, Boonen A, Geenen L, Stulens A, Masin L, Pancho A, et al.
Open Biol
. 2024 Jun;
14(6):240113.
PMID: 38889770
Autism spectrum disorder (ASD) is a group of neurodevelopmental conditions associated with deficits in social interaction and communication, together with repetitive behaviours. The cell adhesion molecule protocadherin10 () is linked...
3.
Pancho A, Mitsogiannis M, Aerts T, Dalla Vecchia M, Ebert L, Geenen L, et al.
Front Neurosci
. 2022 Nov;
16:887478.
PMID: 36389226
PCDH19 is a transmembrane protein and member of the protocadherin family. It is encoded by the X-chromosome and more than 200 mutations have been linked to the neurodevelopmental PCDH-clustering epilepsy...
4.
Kleinberger I, Sanders E, Staes K, Van Troys M, Hirano S, Hochepied T, et al.
BMC Cancer
. 2022 Apr;
22(1):451.
PMID: 35468745
Background: Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a typical single ectodomain and a cytoplasmic domain with conserved motifs completely different from those of classic cadherins. Alternative splice isoforms...
5.
Raghavan R, Koyande N, Beher R, Chetlangia N, Ramadwar M, Pawade S, et al.
Biochem Biophys Res Commun
. 2021 Nov;
586:14-19.
PMID: 34823217
Plakophilin3 (PKP3) loss leads to tumor progression and metastasis of colon cancer cells. The goal of this report was to determine if PKP3 loss led to increased disease progression in...
6.
Pieters T, Sanders E, Tian H, van Hengel J, van Roy F
BMC Dev Biol
. 2020 Aug;
20(1):17.
PMID: 32741376
Background: p120 catenin (p120ctn) is an important component in the cadherin-catenin cell adhesion complex because it stabilizes cadherin-mediated intercellular junctions. Outside these junctions, p120ctn is actively involved in the regulation...
7.
Punovuori K, Migueles R, Malaguti M, Blin G, Macleod K, Carragher N, et al.
Development
. 2019 Oct;
146(21).
PMID: 31601548
A switch from E- to N-cadherin regulates the transition from pluripotency to neural identity, but the mechanism by which cadherins regulate differentiation was previously unknown. Here, we show that the...
8.
Andries V, De Keuckelaere E, Staes K, Hochepied T, Taminau J, Lemeire K, et al.
BMC Cancer
. 2019 Jun;
19(1):598.
PMID: 31208373
Background: NANOS3 is a gene conserved throughout evolution. Despite the quite low conservation of Nanos sequences between different organisms and even between Nanos paralogs, their role in germ cell development...
9.
Gul I, Hulpiau P, Sanders E, van Roy F, van Hengel J
Biosci Rep
. 2018 Nov;
39(8).
PMID: 30482882
Armadillo-repeat-containing protein 8 (Armc8) belongs to the family of armadillo-repeat containing proteins, which have been found to be involved in diverse cellular functions including cell-cell contacts and intracellular signaling. By...
10.
Sikela J, van Roy F
F1000Res
. 2018 Jul;
6:2185.
PMID: 29399325
We are jointly proposing a new name for a protein domain of approximately 65 amino acids that has been previously termed NBPF or DUF1220. Our two labs independently reported the...