Jan Kovar
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Explore the profile of Jan Kovar including associated specialties, affiliations and a list of published articles.
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Articles
78
Citations
871
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Recent Articles
1.
Dusilova T, Kovar J, Lankova I, Thieme L, Hubackova M, Sedivy P, et al.
J Clin Med
. 2024 Oct;
13(20).
PMID: 39458050
: Metabolic-dysfunction-associated steatotic liver disease (MASLD) represents a major clinical complication of obesity. : In this study, we used magnetic resonance (MR) methods to determine the effect of obesity treatment...
2.
Sedivy P, Dusilova T, Setinova B, Pajuelo D, Hajek M, Rossmeislova L, et al.
Nutr Metab Cardiovasc Dis
. 2024 Oct;
34(12):2690-2695.
PMID: 39443278
Background And Aims: Prolonged fasting, which leads to the mobilization of fat from adipose tissue, can result in the development of hepatosteatosis. However, it is not yet known whether the...
3.
Rossmeislova L, Krauzova E, Koc M, Wilhelm M, Sebo V, Varaliova Z, et al.
Heliyon
. 2024 Sep;
10(18):e37875.
PMID: 39328508
Fasting induces significant shifts in substrate utilization with signs of acute insulin resistance (IR), while obesity is associated with chronic IR. Nonetheless, both states substantially influence adipose tissue (AT) function....
4.
Daniel P, Balusikova K, Truksa J, cerny J, Jacek M, Jelinek M, et al.
Toxicol Appl Pharmacol
. 2024 Jun;
489:116993.
PMID: 38870637
We tested the effect of substituents at the (1) C3´, C3´N, (2) C10, and (3) C2-meta-benzoate positions of taxane derivatives on their activity against sensitive versus counterpart paclitaxel-resistant breast (MCF-7)...
5.
Monzo L, Kovar J, Borlaug B, Benes J, Kotrc M, Kroupova K, et al.
Eur J Heart Fail
. 2024 Jun;
26(9):1931-1940.
PMID: 38853653
Aims: Patients with heart failure (HF) display metabolic alterations, including heightened ketogenesis, resulting in increased beta-hydroxybutyrate (β-OHB) formation. We aimed to investigate the determinants and prognostic impact of circulating β-OHB...
6.
Fucik R, Kovar J, Skardova K, Polivka O, Chabiniok R
Int J Numer Method Biomed Eng
. 2024 May;
40(7):e3833.
PMID: 38715357
A mathematical model of myocardial perfusion based on the lattice Boltzmann method (LBM) is proposed and its applicability is investigated in both healthy and diseased cases. The myocardium is conceptualized...
7.
Pavlikova N, Sramek J, Jacek M, Kovar J, Nemcova V
Environ Toxicol Pharmacol
. 2023 Oct;
104:104299.
PMID: 37865351
Decades after most countries banned hexachlorocyclohexane, HCH isomers still pollute the environment. Many studies described HCH as a pro-diabetic factor; nevertheless, the effect of HCH isomers on pancreatic beta-cells remains...
8.
Daniel P, Balusikova K, Vaclavikova R, Seborova K, Ransdorfova S, Valerianova M, et al.
Genes (Basel)
. 2023 Feb;
14(2).
PMID: 36833223
A limited number of studies are devoted to regulating expression in cancer. Hence, we aimed to unveil the regulation of expression in MCF-7 breast cancer cells (with high expression) and...
9.
Benes J, Kotrc M, Kroupova K, Wohlfahrt P, Kovar J, Franekova J, et al.
Sci Rep
. 2022 Jul;
12(1):13038.
PMID: 35906276
The role of metformin (MET) in the treatment of patients with advanced HFrEF and type 2 diabetes mellitus (DM) is not firmly established. We studied the impact of MET on...
10.
Balusikova K, Dostalikova-Cimburova M, Tacheci I, Kovar J
J Cell Mol Med
. 2022 Apr;
26(10):2995-3004.
PMID: 35445529
Duodenal biopsies are considered a suitable source of enterocytes for studies of dietary iron absorption. However, the expression level of molecules involved in iron absorption may vary along the length...