Vlasta Nemcova-Furstova
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Explore the profile of Vlasta Nemcova-Furstova including associated specialties, affiliations and a list of published articles.
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17
Citations
266
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Recent Articles
1.
Sramek J, Nemcova-Furstova V, Kovar J
Int J Mol Sci
. 2021 Apr;
22(8).
PMID: 33924206
Pancreatic β-cell failure and death contribute significantly to the pathogenesis of type 2 diabetes. One of the main factors responsible for β-cell dysfunction and subsequent cell death is chronic exposure...
2.
Sramek J, Nemcova-Furstova V, Polak J, Kovar J
Int J Mol Sci
. 2019 Jul;
20(14).
PMID: 31336948
Saturated fatty acids (FAs) induce apoptosis in the human pancreatic NES2Y β-cell line while unsaturated FAs have nearly no detrimental effect. Moreover, unsaturated FAs are capable of inhibiting the pro-apoptotic...
3.
Nemcova-Furstova V, Balusikova K, Halada P, Pavlikova N, Sramek J, Kovar J
Proteomics Clin Appl
. 2019 Jan;
13(4):e1800104.
PMID: 30666801
Purpose: Lipotoxicity is implicated in type 2 diabetes pathogenesis. Its molecular mechanisms are not completely understood. The aim of this study is to identify new suspect proteins involved in pancreatic...
4.
Jelinek M, Balusikova K, Daniel P, Nemcova-Furstova V, Kirubakaran P, Jacek M, et al.
Toxicol Appl Pharmacol
. 2018 Apr;
347:79-91.
PMID: 29625142
We tested the role of substituents at the C3' and C3'N positions of the taxane molecule to identify taxane derivatives capable of overcoming acquired resistance to paclitaxel. Paclitaxel-resistant sublines SK-BR-3/PacR...
5.
Sramek J, Nemcova-Furstova V, Pavlikova N, Kovar J
Int J Mol Sci
. 2017 Nov;
18(11).
PMID: 29099080
It has been shown that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to apoptosis, whereas unsaturated FAs are well tolerated and are...
6.
Nemcova-Furstova V, Kopperova D, Balusikova K, Ehrlichova M, Brynychova V, Vaclavikova R, et al.
Toxicol Appl Pharmacol
. 2016 Sep;
310:215-228.
PMID: 27664577
Development of taxane resistance has become clinically very important issue. The molecular mechanisms underlying the resistance are still unclear. To address this issue, we established paclitaxel-resistant sublines of the SK-BR-3...
7.
Sramek J, Nemcova-Furstova V, Kovar J
Int J Mol Sci
. 2016 Sep;
17(9).
PMID: 27626409
Pancreatic β-cell failure and death is considered to be one of the main factors responsible for type 2 diabetes. It is caused by, in addition to hyperglycemia, chronic exposure to...
8.
Brynychova V, Ehrlichova M, Hlavac V, Nemcova-Furstova V, Pecha V, Leva J, et al.
Biomed Pharmacother
. 2016 Aug;
83:857-864.
PMID: 27505863
Microtubules are vitally important for eukaryotic cell division. Therefore, we evaluated the relevance of mitotic kinesin KIF14, protein-regulating cytokinesis 1 (PRC1), and citron kinase (CIT) for the prognosis of breast...
9.
Brynychova V, Hlavac V, Ehrlichova M, Vaclavikova R, Nemcova-Furstova V, Pecha V, et al.
Clin Chem Lab Med
. 2016 Jun;
55(1):111-122.
PMID: 27327132
Background: Apoptosis plays a critical role in cancer cell survival and tumor development. We provide a hypothesis-generating screen for further research by exploring the expression profile and genetic variability of...
10.
Sramek J, Nemcova-Furstova V, Balusikova K, Daniel P, Jelinek M, James R, et al.
Int J Mol Sci
. 2016 Feb;
17(2):159.
PMID: 26861294
Saturated stearic acid (SA) induces apoptosis in the human pancreatic β-cells NES2Y. However, the molecular mechanisms involved are unclear. We showed that apoptosis-inducing concentrations of SA activate the p38 MAPK...