Jan Kovar
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Explore the profile of Jan Kovar including associated specialties, affiliations and a list of published articles.
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78
Citations
871
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Recent Articles
11.
Seborova K, Kloudova-Spalenkova A, Koucka K, Holy P, Ehrlichova M, Wang C, et al.
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008510
The main problem precluding successful therapy with conventional taxanes is de novo or acquired resistance to taxanes. Therefore, novel experimental taxane derivatives (Stony Brook taxanes; SB-Ts) are synthesized and tested...
12.
Sramek J, Nemcova V, Kovar J
Nutr Metab (Lond)
. 2021 Jul;
18(1):74.
PMID: 34274001
It was evidenced that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to endoplasmic reticulum (ER) calcium release, ER stress, and apoptosis. In...
13.
Kyselak O, Soska V, Kovar J, Tichy L, Grombirikova H, Hubacek J, et al.
J Clin Lipidol
. 2021 May;
15(3):435-440.
PMID: 33975813
We describe the casuistry of a homozygous familial hypercholesterolemia female patient with a biallelic missense variant (NM_000527.4:c.1775G>A, p.Gly592Glu) in the LDLR gene, severe hypertriglyceridemia and late manifestation of coronary heart...
14.
Sramek J, Nemcova-Furstova V, Kovar J
Int J Mol Sci
. 2021 Apr;
22(8).
PMID: 33924206
Pancreatic β-cell failure and death contribute significantly to the pathogenesis of type 2 diabetes. One of the main factors responsible for β-cell dysfunction and subsequent cell death is chronic exposure...
15.
Pavlikova N, Sramek J, Jelinek M, Halada P, Kovar J
PLoS One
. 2020 Oct;
15(10):e0229430.
PMID: 33104727
Many compounds have the potential to harm pancreatic beta-cells; organochlorine pollutants belong to those compounds. In this work, we aimed to find markers of acute toxicity of p,p'-DDT exposure among...
16.
cermak V, Dostal V, Jelinek M, Libusova L, Kovar J, Rosel D, et al.
Eur J Cell Biol
. 2020 May;
99(4):151075.
PMID: 32414588
Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that bind to microtubules and affect their properties and function. Disruption of microtubules induces various cellular responses often leading to...
17.
Sedivy P, Dezortova M, Drobny M, Dubsky M, Dusilova T, Kovar J, et al.
NMR Biomed
. 2020 Mar;
33(6):e4295.
PMID: 32180296
An unknown intense signal (P ) with a mean chemical shift of 5.3 ppm was observed in P MR spectra from the calf muscles of patients with the diabetic foot...
18.
Poledne R, Kovar J
Vnitr Lek
. 2020 Feb;
65(12):783-787.
PMID: 32013521
The history of studying hypertriglyceridemia as a risk factor for atherosclerosis has been going on for a half a century. The significance of this parameter as measured in fasting state...
19.
Pavlikova N, Daniel P, Sramek J, Jelinek M, Sramkova V, Nemcova V, et al.
Sci Rep
. 2019 Dec;
9(1):18026.
PMID: 31792309
Persistent organochlorine pollutants (POPs) gradually accumulate in the human organism due to their presence in the environment. Some studies have described a correlation between the level of POPs in the...
20.
Sramek J, Nemcova-Furstova V, Polak J, Kovar J
Int J Mol Sci
. 2019 Jul;
20(14).
PMID: 31336948
Saturated fatty acids (FAs) induce apoptosis in the human pancreatic NES2Y β-cell line while unsaturated FAs have nearly no detrimental effect. Moreover, unsaturated FAs are capable of inhibiting the pro-apoptotic...