Jan Kosla
Overview
Explore the profile of Jan Kosla including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
682
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0
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Recent Articles
1.
Outla Z, Oyman-Eyrilmez G, Korelova K, Prechova M, Frick L, Sarnova L, et al.
Elife
. 2025 Mar;
13.
PMID: 40052672
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays...
2.
Rasl J, Caslavsky J, Grusanovic J, Chvalova V, Kosla J, Adamec J, et al.
Cell Signal
. 2024 Jul;
121:111295.
PMID: 38996955
Calpain2 is a conventional member of the non-lysosomal calpain protease family that has been shown to affect the dynamics of focal and cell-cell adhesions by proteolyzing the components of adhesion...
3.
Gallage S, Ali A, Barragan Avila J, Seymen N, Ramadori P, Joerke V, et al.
Cell Metab
. 2024 May;
36(6):1371-1393.e7.
PMID: 38718791
The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic steatohepatitis (NASH) and its transition to hepatocellular carcinoma (HCC) are unknown. Here, we identified that an IF 5:2 regimen...
4.
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment
Hornofova T, Pokorna B, Hubackova S, Uvizl A, Kosla J, Bartek J, et al.
DNA Repair (Amst)
. 2022 Mar;
114:103319.
PMID: 35325646
Repetitive sequences are among the most unstable regions in the eukaryotic genome and defects in their maintenance correlate with premature aging and cancer development. Promyelocytic leukemia protein (PML) induces accumulation...
5.
Pfister D, Gonzalo Nunez N, Pinyol R, Govaere O, Pinter M, Szydlowska M, et al.
Nature
. 2021 Mar;
592(7854):450-456.
PMID: 33762733
Hepatocellular carcinoma (HCC) can have viral or non-viral causes. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of patients...
6.
Krchlikova V, Mikesova J, Geryk J, Barinka C, Nexo E, Fedosov S, et al.
J Virol
. 2021 Jan;
95(8).
PMID: 33504597
The Avian sarcoma and leukosis viruses (ASLVs) are important chicken pathogens. Some of the virus subgroups, including ASLV-A and K, utilize the Tva receptor for cell entrance. Though Tva was...
7.
OConnor T, Zhou X, Kosla J, Adili A, Beccaria M, Kotsiliti E, et al.
Cancer Cell
. 2019 Sep;
36(3):250-267.e9.
PMID: 31526758
How lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated...
8.
Imrichova T, Hubackova S, Kucerova A, Kosla J, Bartek J, Hodny Z, et al.
Aging (Albany NY)
. 2019 Sep;
11(17):7206-7235.
PMID: 31493766
Diverse stress insults trigger interactions of PML with nucleolus, however, the function of these PML nucleolar associations (PNAs) remains unclear. Here we show that during induction of DNA damage-induced senescence...
9.
Vancurova M, Hanzlikova H, Knoblochova L, Kosla J, Majera D, Mistrik M, et al.
DNA Repair (Amst)
. 2019 Apr;
78:114-127.
PMID: 31009828
The bulk of DNA damage caused by ionizing radiation (IR) is generally repaired within hours, yet a subset of DNA lesions may persist even for long periods of time. Such...
10.
Lorentzen A, Becker P, Kosla J, Saini M, Weidele K, Ronchi P, et al.
Nat Commun
. 2018 Mar;
9(1):887.
PMID: 29491397
Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment...