Jan Horstkotte
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Explore the profile of Jan Horstkotte including associated specialties, affiliations and a list of published articles.
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21
Citations
840
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Recent Articles
1.
Desch S, Freund A, Akin I, Behnes M, Preusch M, Zelniker T, et al.
JAMA Cardiol
. 2023 Aug;
8(9):827-834.
PMID: 37556123
Importance: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect of early coronary angiography on patients with OHCA with possible coronary trigger but no ST-segment...
2.
Desch S, Freund A, Akin I, Behnes M, Preusch M, Zelniker T, et al.
N Engl J Med
. 2021 Aug;
385(27):2544-2553.
PMID: 34459570
Background: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest. However, the benefits of early coronary angiography and revascularization in resuscitated patients without electrocardiographic evidence of ST-segment elevation are...
3.
Desch S, Freund A, Graf T, Fichtlscherer S, Haake H, Preusch M, et al.
Am Heart J
. 2019 Jan;
209:20-28.
PMID: 30639610
Patients experiencing out-of-hospital cardiac arrest (OHCA) without ST-segment elevation are a heterogenic group with a variety of underlying causes. Up to one-third of patients display a significant coronary lesion compatible...
4.
Sibbing D, Aradi D, Jacobshagen C, Gross L, Trenk D, Geisler T, et al.
Thromb Haemost
. 2016 Sep;
117(1):188-195.
PMID: 27652610
Outcomes of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) have been significantly improved with the use of potent P2Y receptor inhibitors like prasugrel. While most of the...
5.
Ziegler T, Horstkotte M, Lange P, Ng J, Bongiovanni D, Hinkel R, et al.
Thromb Haemost
. 2016 Jul;
116(2):300-8.
PMID: 27412300
Advanced glycation end-products (AGEs) interact with their receptor RAGE, leading to an inflammatory state. We investigated the role of RAGE in postischaemic leukocyte adhesion after myocardial infarction and its effect...
6.
Horstkotte J, Kloeser C, Beucher H, Schwarzlaender E, von Bardeleben R, Boekstegers P
Catheter Cardiovasc Interv
. 2016 Apr;
88(7):1134-1143.
PMID: 27038227
Introduction: Intraprocedural assessment of mitral regurgitation (MR) is a challenging issue during the MitraClip procedure, which might influence not only the position but also the number of MitraClips implanted. Though...
7.
Hinkel R, Lange P, Petersen B, Gottlieb E, Man Ng J, Finger S, et al.
J Am Coll Cardiol
. 2015 Jul;
66(2):154-65.
PMID: 26160631
Background: Heme oxygenase-1 (HO-1) is an inducible stress-responsive enzyme converting heme to bilirubin, carbon monoxide, and free iron, which exerts anti-inflammatory and antiapoptotic effects. Although efficient cardioprotection after HO-1 overexpression...
8.
Kucher N, Boekstegers P, Muller O, Kupatt C, Beyer-Westendorf J, Heitzer T, et al.
Circulation
. 2013 Nov;
129(4):479-86.
PMID: 24226805
Background: In patients with acute pulmonary embolism, systemic thrombolysis improves right ventricular (RV) dilatation, is associated with major bleeding, and is withheld in many patients at risk. This multicenter randomized,...
9.
Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, et al.
J Clin Invest
. 2013 Jul;
PMID: 23863629
Septic shock is characterized by increased vascular permeability and hypotension despite increased cardiac output. Numerous vasoactive cytokines are upregulated during sepsis, including angiopoietin 2 (ANG2), which increases vascular permeability. Here...
10.
Rehberg M, Leite C, Mildner K, Horstkotte J, Zeuschner D, Krombach F
ACS Nano
. 2012 Jan;
6(2):1370-9.
PMID: 22243127
The behavior of quantum dots (QDs) in the microvasculature and their impact on inflammatory reactions under pathophysiological conditions are still largely unknown. Therefore, we designed this study to investigate the...