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Jan de Boer

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Articles 158
Citations 4864
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Recent Articles
1.
Kooi R, Schoutens E, Stassen O, Stassen O, de Boer J, den Toonder J
Prog Biomed Eng (Bristol) . 2025 Mar; PMID: 40043363
Mechanical forces of various kinds and magnitudes are crucial to cell and tissue development. At the cell level, mechanotransduction refers to the processes that turn mechanical triggers into a biochemical...
2.
Schmitz M, Aarts J, Burroughs L, Sudarsanam P, Kuijpers T, Riool M, et al.
Macromol Rapid Commun . 2024 Mar; :e2300638. PMID: 38530968
A polymer microarray based on the supramolecular ureido-pyrimidinone (UPy) moiety is fabricated to screen antimicrobial materials for their ability to support cell adhesion. UPy-functionalized additives, either cell-adhesive, antimicrobial or control...
3.
Sudarsanam P, Alsema E, Beijer N, Kooten T, de Boer J
Tissue Eng Part B Rev . 2024 Feb; 30(6):596-606. PMID: 38420650
The foreign body response (FBR) and organ fibrosis are complex biological processes involving the interaction between macrophages and fibroblasts. Understanding the molecular mechanisms underlying macrophage-fibroblast cross talk is crucial for...
4.
Teijema J, Hofstee L, Brouwer M, de Bruin J, Ferdinands G, de Boer J, et al.
Front Res Metr Anal . 2023 Jun; 8:1178181. PMID: 37260784
Introduction: This study examines the performance of active learning-aided systematic reviews using a deep learning-based model compared to traditional machine learning approaches, and explores the potential benefits of model-switching strategies....
5.
van Mechelen R, Sudarsanam P, Bertens C, Tas M, Gijbels M, Pinchuk L, et al.
Adv Biol (Weinh) . 2023 Apr; 7(7):e2300051. PMID: 37102630
Lowering intraocular pressure (IOP) by placement of a glaucoma shunt is an effective treatment for glaucoma. However, fibrosis of the outflow site can hamper surgical outcome. In this study, the...
6.
Juni R, Kocken J, Abreu R, Ottaviani L, Davalan T, Duygu B, et al.
Mol Ther . 2023 Apr; 31(6):1807-1828. PMID: 37073128
While it is experimentally supported that impaired myocardial vascularization contributes to a mismatch between myocardial oxygen demand and supply, a mechanistic basis for disruption of coordinated tissue growth and angiogenesis...
7.
Vermeulen S, Van Puyvelde B, Bengtsson Del Barrio L, Almey R, van der Veer B, Deforce D, et al.
Adv Sci (Weinh) . 2022 Nov; :e2203880. PMID: 36414384
Biomaterials can control cell and nuclear morphology. Since the shape of the nucleus influences chromatin architecture, gene expression and cell identity, surface topography can control cell phenotype. This study provides...
8.
Uquillas J, Spierings J, van der Lande A, Eren A, Bertrand M, Yuan H, et al.
J Mech Behav Biomed Mater . 2022 Sep; 135:105452. PMID: 36122497
Approximately 1% of active individuals participating in sports rupture their anterior cruciate ligaments (ACL) every year, which is currently reconstructed using tendon autografts. Upon reconstruction, clinical issues of concern are...
9.
Eren A, Lucassen A, Tuvshindorj U, Truckenmuller R, Giselbrecht S, Eren E, et al.
Front Cell Dev Biol . 2022 Jun; 10:863721. PMID: 35721512
Cells probe their environment and adapt their shape accordingly the organization of focal adhesions and the actin cytoskeleton. In an earlier publication, we described the relationship between cell shape and...
10.
Eren A, Vermeulen S, Schmitz T, Foolen J, de Boer J
Acta Biomater . 2022 May; 163:275-286. PMID: 35584748
Cells and their surrounding extracellular matrix (ECM) are engaged in dynamic reciprocity to maintain tissue homeostasis: cells deposit ECM, which in turn presents the signals that define cell identity. This...