Jan C Heinemann
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Explore the profile of Jan C Heinemann including associated specialties, affiliations and a list of published articles.
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11
Citations
104
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Recent Articles
1.
Biederbick C, Heinemann J, Rieck S, Winkler F, Ottersbach A, Schiffer M, et al.
Theranostics
. 2023 Feb;
13(3):1150-1164.
PMID: 36793861
The regenerative potential of the heart after injury is limited. Therefore, cell replacement strategies have been developed. However, the engraftment of transplanted cells in the myocardium is very inefficient. In...
2.
Duerr G, Heinemann J, Kley J, Eichhorn L, Frede S, Weisheit C, et al.
J Mol Cell Cardiol
. 2019 Jun;
133:86-98.
PMID: 31181227
Background: Adaptation to aortic valve stenosis leads to myocardial hypertrophy, which has been associated with inflammation, fibrosis and activation of the endocannabinoid system. Since the endocannabinoid system and the CB2...
3.
Gestrich C, Duerr G, Heinemann J, Meertz A, Probst C, Roell W, et al.
Biomed Res Int
. 2015 Nov;
2015:456582.
PMID: 26539497
Human aortic aneurysms have been associated with inflammation and vascular remodeling. Since the endocannabinoid system modulates inflammation and tissue remodeling, we investigated its components in human aortic aneurysms. We obtained...
4.
Heinemann J, Duerr G, Keppel K, Breitbach M, Fleischmann B, Zimmer A, et al.
Life Sci
. 2014 Dec;
138:18-28.
PMID: 25497711
Aims: The endocannabinoid system and cannabinoid receptor 2 (CB2 receptor) have been associated with modulation of inflammatory response and myocardial adaptation after ischemic injury. In order to elucidate CB2 receptor-related...
5.
Duerr G, Heinemann J, Gestrich C, Heuft T, Klaas T, Keppel K, et al.
Life Sci
. 2014 Dec;
138:8-17.
PMID: 25447445
Aims: Reperfusion ofmyocardial infarction is associated with inflammatory reaction and subsequentmyocardial remodeling with a rapid scar formation in mice. The cannabinoid receptor CB2 has been associated with cardioprotection and regulation...
6.
Duerr G, Heinemann J, Suchan G, Kolobara E, Wenzel D, Geisen C, et al.
Basic Res Cardiol
. 2014 Jul;
109(4):425.
PMID: 24980781
Ischemic heart disease is associated with inflammation, interstitial fibrosis and ventricular dysfunction prior to the development of heart failure. Endocannabinoids and the cannabinoid receptor CB2 have been claimed to be...
7.
Duerr G, Mesenholl B, Heinemann J, Zoerlein M, Huebener P, Schneider P, et al.
Biomed Res Int
. 2014 Jun;
2014:124063.
PMID: 24971311
Repetitive brief ischemia and reperfusion (I/R) is associated with ventricular dysfunction in pathogenesis of murine ischemic cardiomyopathy and human hibernating myocardium. We investigated the role of matricellular protein osteopontin-1 (OPN)...
8.
Duerr G, Heinemann J, Arnoldi V, Feisst A, Kley J, Ghanem A, et al.
Life Sci
. 2014 Mar;
102(2):88-97.
PMID: 24657893
Aims: Peroxisome proliferator-activated receptor (PPAR)-α is downregulated in ischemic myocardium resulting in substrate switch from fatty acid oxidation to glucose utilization. Pharmacological PPAR-α activation leads to increased fatty acid oxidation...
9.
Duerr G, Heinemann J, Dunkel S, Zimmer A, Lutz B, Lerner R, et al.
Life Sci
. 2013 Apr;
92(20-21):976-83.
PMID: 23567807
Aims: Endocannabinoids and their receptors have been associated with cardiac adaptation to injury, inflammation and fibrosis. Experimental studies suggested a role for inflammatory reaction and active remodeling in myocardial hypertrophy,...
10.
Wenzel D, Koch M, Matthey M, Heinemann J, Fleischmann B
Hypertension
. 2012 May;
59(6):1256-62.
PMID: 22547445
Some small molecular weight peptides possess potent vasoactive properties. Herein we have identified the laminin nonapeptide (LNP) CDPGYIGSR as a novel vasoconstrictive agent. Isometric force measurements revealed that LNP induced...