Jan Attig
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Explore the profile of Jan Attig including associated specialties, affiliations and a list of published articles.
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33
Citations
1652
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Recent Articles
1.
OBrien N, Mueller J, Broske A, Attig J, Osl F, Crisand C, et al.
MAbs
. 2024 Dec;
17(1):2440578.
PMID: 39686589
T cell bispecific antibodies (TCBs) are a promising new class of therapeutics for relapsed/refractory multiple myeloma. A frequently observed, yet incompletely understood effect of this treatment is the transient reduction...
2.
Eckmann J, Fauti T, Biehl M, Zabaleta A, Blanco L, Lelios I, et al.
Blood
. 2024 Oct;
145(2):202-219.
PMID: 39476124
Despite several approved therapies, multiple myeloma (MM) remains an incurable disease with high unmet medical need. "Off-the-shelf" T-cell bispecific antibodies (TCBs) targeting B-cell maturation antigen (BCMA) and G protein-coupled receptor...
3.
Reis B, Attig J, Dziadek S, Graefe N, Heller A, Rieder N, et al.
Front Immunol
. 2024 Mar;
15:1285049.
PMID: 38455061
Background: Downregulation of MHC class I expression and/or defects in the antigen presentation pathways are commonly reported in human cancers. Numerous studies previously have explored extensively the molecular mechanisms that...
4.
Kazachenka A, Loong J, Attig J, Young G, Ganguli P, Devonshire G, et al.
NAR Cancer
. 2023 Jul;
5(3):zcad040.
PMID: 37502711
Most cancer types exhibit aberrant transcriptional activity, including derepression of retrotransposable elements (RTEs). However, the degree, specificity and potential consequences of RTE transcriptional activation may differ substantially among cancer types...
5.
Attig J, Pape J, Doglio L, Kazachenka A, Ottina E, Young G, et al.
J Clin Invest
. 2023 May;
133(14).
PMID: 37192000
Increased levels and diversity of human endogenous retrovirus (HERV) transcription characterize most cancer types and are linked with disease outcomes. However, the underlying processes are incompletely understood. Here, we show...
6.
Ng K, Boumelha J, Enfield K, Almagro J, Cha H, Pich O, et al.
Nature
. 2023 Apr;
616(7957):563-573.
PMID: 37046094
B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS). Although TLS have been found to correlate...
7.
Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, et al.
Cancer Cell
. 2021 Oct;
39(11):1497-1518.e11.
PMID: 34715028
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the...
8.
Lima-Junior D, Krishnamurthy S, Bouladoux N, Collins N, Han S, Chen E, et al.
Cell
. 2021 Jun;
184(14):3794-3811.e19.
PMID: 34166614
The microbiota plays a fundamental role in regulating host immunity. However, the processes involved in the initiation and regulation of immunity to the microbiota remain largely unknown. Here, we show...
9.
Ottina E, Panova V, Doglio L, Kazachenka A, Cornish G, Kirkpatrick J, et al.
Oncogene
. 2021 Jun;
40(37):5567-5578.
PMID: 34145398
The ubiquitin-proteasome system maintains protein homoeostasis, underpins the cell cycle, and is dysregulated in cancer. However, the role of individual E3 ubiquitin ligases, which mediate the final step in ubiquitin-mediated...
10.
Agostini F, Zagalak J, Attig J, Ule J, Luscombe N
Genome Biol
. 2021 May;
22(1):136.
PMID: 33952325
Background: Eukaryotic genomes undergo pervasive transcription, leading to the production of many types of stable and unstable RNAs. Transcription is not restricted to regions with annotated gene features but includes...