Jan A Gorter
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Explore the profile of Jan A Gorter including associated specialties, affiliations and a list of published articles.
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85
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2694
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Recent Articles
1.
Rozeboom A, Broekaart D, Anink J, Boonkamp L, Idema S, Teunissen C, et al.
Exp Neurol
. 2025 Jan;
386:115149.
PMID: 39842492
Decreased capillary expression of low-density lipoprotein receptor-related protein 1 (LRP1) has been linked to increased brain amyloid beta (Aβ) accumulation in Alzheimer's disease (AD). Aβ accumulation has also been observed...
2.
van Vliet E, Scheper M, Mills J, Puhakka N, Szydlowska K, Ferracin M, et al.
Epilepsia
. 2024 Oct;
65(11):3406-3420.
PMID: 39352406
Objective: Structural epilepsies can manifest months or years after the occurrence of an initial epileptogenic insult, making them amenable for secondary prevention. However, development of preventive treatments has been challenged...
3.
Meijer W, Gorter J
Epilepsia
. 2024 Aug;
65(9):2519-2536.
PMID: 39101543
Stroke is a major contributor to mortality and morbidity worldwide and the most common cause of epilepsy in the elderly in high income nations. In recent years, it has become...
4.
Meeusen H, Kalf R, Broekaart D, Silva J, Verkuyl J, van Helvoort A, et al.
Exp Neurol
. 2024 Jun;
379:114861.
PMID: 38876196
Drug-resistant epilepsy patients may benefit from non-pharmacological therapies, such as the ketogenic diet (KD). However, its high fat content poses compliance challenges and metabolic risks. To mitigate this, we developed...
5.
Meeusen H, Romagnolo A, Holsink S, van den Broek T, van Helvoort A, Gorter J, et al.
Sci Rep
. 2024 May;
14(1):11940.
PMID: 38789658
The classic ketogenic diet is an effective treatment option for drug-resistant epilepsy, but its high fat content challenges patient compliance. Optimizing liver ketone production guided by a method comparing substrates...
6.
Broekaart D, Zimmer T, Cohen S, Tessers R, Anink J, de Vries H, et al.
Biomedicines
. 2022 Sep;
10(9).
PMID: 36140216
Matrix metalloproteinases (MMPs) are endopeptidases responsible for the cleavage of intra- and extracellular proteins. Several brain MMPs have been implicated in neurological disorders including epilepsy. We recently showed that the...
7.
Mills J, Iyer A, van Scheppingen J, Bongaarts A, Anink J, Janssen B, et al.
Sci Rep
. 2022 Sep;
12(1):15457.
PMID: 36104396
No abstract available.
8.
Drion C, Kooijman L, Chan D, Berkhout J, van Vliet E, Wadman W, et al.
Epilepsy Res
. 2022 Feb;
181:106873.
PMID: 35180639
Purpose: Curcumin is known for its neuroprotective, anti-inflammatory and anti-oxidant properties and has been investigated as a potential therapeutic drug for Temporal Lobe Epilepsy (TLE). We previously found anti-epileptogenic properties...
9.
Zimmer T, David B, Broekaart D, Schidlowski M, Ruffolo G, Korotkov A, et al.
Acta Neuropathol
. 2021 Jul;
142(4):729-759.
PMID: 34292399
Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, to date, alterations in iron...
10.
Broekaart D, Bertran A, Jia S, Korotkov A, Senkov O, Bongaarts A, et al.
J Clin Invest
. 2020 Nov;
131(1).
PMID: 33141761
Matrix metalloproteinases (MMPs) are synthesized by neurons and glia and released into the extracellular space, where they act as modulators of neuroplasticity and neuroinflammatory agents. Development of epilepsy (epileptogenesis) is...