James W Yockman
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Explore the profile of James W Yockman including associated specialties, affiliations and a list of published articles.
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28
Citations
489
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Recent Articles
1.
Hu N, Sabey K, Curtis H, Hoang N, Dowdle S, Garzarelli A, et al.
Comp Med
. 2012 May;
62(2):116-23.
PMID: 22546917
To understand the structure-function relationship in the postinfarcted myocardium in rabbits, we induced cardiac ischemia by ligating the left circumflex coronary artery. Sham controls underwent thoracotomy only. At 7 and...
2.
Lee Y, Nam H, Kim J, Lee M, Yockman J, Shin S, et al.
Mol Ther
. 2012 Apr;
20(7):1360-6.
PMID: 22472948
Erythropoiesis-stimulating agents are widely used to treat anemia for chronic kidney disease (CKD) and cancer, however, several clinical limitations impede their effectiveness. Nonviral gene therapy systems are a novel solution...
3.
Brumbach J, Lee Y, Kim S, Yockman J
J Control Release
. 2012 Jan;
159(1):111-9.
PMID: 22286007
The clinical success of non-viral gene delivery reagents is hampered by their inefficient cellular transgene delivery, which is largely influenced by carrier properties that are currently undefined and misunderstood. In...
4.
Kim P, Kim J, Kim T, Nam H, Yockman J, Kim M, et al.
Biomaterials
. 2011 Sep;
32(35):9328-42.
PMID: 21924767
Systemic administration of adenovirus (Ad) vectors is complicated by host immune responses and viral accumulation in the liver, resulting in a short circulatory virus half-life, low efficacy, and host side...
5.
Nam H, Kim J, Kim S, Yockman J, Kim S, Bull D
Biomaterials
. 2011 Apr;
32(22):5213-22.
PMID: 21501867
The primary cardiomyocyte-specific peptide (PCM) and the cell-penetrating peptide (CPP), HIV-Tat (49-57), were incorporated into the polymer, cystamine bisacrylamide-diaminohexane (CBA-DAH), to increase the delivery of RNAi to target cells, specifically...
6.
Hu N, Straub C, Garzarelli A, Sabey K, Yockman J, Bull D
J Am Assoc Lab Anim Sci
. 2011 Jan;
49(6):838-44.
PMID: 21205450
Provided is the surgical procedure for ligating the left circumflex coronary artery to simulate heart ischemia by using a rabbit model. Heart rate monitored by electrocardiogram was increased at 5...
7.
Bioreducible polymer-transfected skeletal myoblasts for VEGF delivery to acutely ischemic myocardium
McGinn A, Nam H, Ou M, Hu N, Straub C, Yockman J, et al.
Biomaterials
. 2010 Oct;
32(3):942-9.
PMID: 20970850
Implantation of skeletal myoblasts to the heart has been investigated as a means to regenerate and protect the myocardium from damage after myocardial infarction. While several animal studies utilizing skeletal...
8.
Tran V, Victor X, Yockman J, Kuberan B
Glycoconj J
. 2010 Aug;
27(6):625-33.
PMID: 20717719
Glycosaminoglycans (GAG) play decisive roles in various cardio-vascular & cancer-associated processes. Changes in the expression of GAG fine structures, attributed to deregulation of their biosynthetic and catabolic enzymes, are hallmarks...
9.
Dual bio-responsive gene delivery via reducible poly(amido amine) and survivin-inducible plasmid DNA
Namgung R, Brumbach J, Jeong J, Yockman J, Kim S, Lin C, et al.
Biotechnol Lett
. 2010 Feb;
32(6):755-64.
PMID: 20155385
A bioreducible poly(amido amine) (SS-PAA) gene carrier, known as poly (amido-butanol) (pABOL), was used to transfect a variety of cancer and non-cancer cell lines. To obtain cancer-specific transgene expression for...
10.
Kim P, Kim T, Yockman J, Kim S, Yun C
Biomaterials
. 2009 Dec;
31(7):1865-74.
PMID: 19962189
Adenoviral vectors offer many advantages for cancer gene therapy, including high transduction efficiency, but safety concerns related to severe immunogenicity and other side effects have led to careful reconsideration of...