James S Rush
Overview
Explore the profile of James S Rush including associated specialties, affiliations and a list of published articles.
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22
Citations
584
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Recent Articles
1.
Fisher B, Szanto A, Ng W, Bombardieri M, Posch M, Papas A, et al.
Lancet Rheumatol
. 2024 Jan;
2(3):e142-e152.
PMID: 38263652
Background: Primary Sjögren's syndrome is an autoimmune disease that presents as dryness of the mouth and eyes due to impairment of the exocrine glands. To our knowledge, no systemic therapies...
2.
GomezMancilla B, Meriggioli M, Genge A, Roubenoff R, Espie P, Dupuy C, et al.
J Clin Neurosci
. 2023 Nov;
119:76-84.
PMID: 37988976
Background: Increased morbidity in many patients with myasthenia gravis (MG) on long-term immunosuppression highlights the need for improved treatments. The aim of this study is to investigate the safety and...
3.
Shi T, Burg A, Caldwell J, Roskin K, Castro-Rojas C, Chukwuma P, et al.
J Clin Invest
. 2023 May;
133(14).
PMID: 37227784
Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding of how rejection occurs despite...
4.
Hawtin S, Andre C, Collignon-Zipfel G, Appenzeller S, Bannert B, Baumgartner L, et al.
Cell Rep Med
. 2023 May;
4(5):101036.
PMID: 37196635
Genetic and in vivo evidence suggests that aberrant recognition of RNA-containing autoantigens by Toll-like receptors (TLRs) 7 and 8 drives autoimmune diseases. Here we report on the preclinical characterization of...
5.
Shi T, Burg A, Caldwell J, Roskin K, Castro-Rojas C, Chukwuma P, et al.
bioRxiv
. 2023 Feb;
PMID: 36798151
Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding. We performed combined single cell...
6.
Hoyler T, Bannert B, Andre C, Beck D, Boulay T, Buffet D, et al.
JCI Insight
. 2022 Jul;
7(13).
PMID: 35801586
IL-1 receptor-activated kinase 1 (IRAK1) is involved in signal transduction downstream of many TLRs and the IL-1R. Its potential as a drug target for chronic inflammatory diseases is underappreciated. To...
7.
Willemsen J, Neuhoff M, Hoyler T, Noir E, Tessier C, Sarret S, et al.
Cell Rep
. 2021 Nov;
37(6):109977.
PMID: 34758308
Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which affected tissues show an interferon-stimulated gene signature....
8.
Begley C, Ashton M, Baell J, Bettess M, Brown M, Carter B, et al.
Sci Transl Med
. 2021 Sep;
13(612):eabd5524.
PMID: 34550729
Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines. Often, however, there is insufficient consideration by academic researchers of the processes required to ensure that...
9.
Edner N, Carlesso G, Rush J, Walker L
Nat Rev Drug Discov
. 2020 Nov;
20(1):82.
PMID: 33208921
No abstract available.
10.
Edner N, Carlesso G, Rush J, Walker L
Nat Rev Drug Discov
. 2020 Sep;
19(12):860-883.
PMID: 32939077
Therapeutic targeting of immune checkpoints has garnered significant attention in the area of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T lymphocyte antigen 4 (CTLA4) and...