James R Vasselli
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Explore the profile of James R Vasselli including associated specialties, affiliations and a list of published articles.
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12
Citations
1093
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Recent Articles
1.
Woldemichael G, Turbyville T, Vasselli J, Linehan W, McMahon J
Neoplasia
. 2012 Sep;
14(8):771-7.
PMID: 22952429
Verrucarin A (VA) is a small molecule derived from the fungal plant pathogen Myrothecium verrucaria and was identified as a selective inhibitor of clear cell renal cell carcinoma (CCRCC) cell...
2.
Wells Jr S, Robinson B, Gagel R, Dralle H, Fagin J, Santoro M, et al.
J Clin Oncol
. 2011 Oct;
30(2):134-41.
PMID: 22025146
Purpose: There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth...
3.
Lee S, Lattouf J, Xanthopoulos J, Linehan W, Bottaro D, Vasselli J
Eur Urol
. 2008 Feb;
54(4):845-53.
PMID: 18243508
Objectives: Clear-cell renal cell carcinoma (RCC) is the most prevalent form of kidney cancer and is frequently associated with loss of von Hippel-Lindau (VHL) gene function, resulting in the aberrant...
4.
Giubellino A, Gao Y, Lee S, Lee M, Vasselli J, Medepalli S, et al.
Cancer Res
. 2007 Jul;
67(13):6012-6.
PMID: 17616655
Metastasis, the primary cause of death in most forms of cancer, is a multistep process whereby cells from the primary tumor spread systemically and colonize distant new sites. Blocking critical...
5.
Woldemichael G, Vasselli J, Gardella R, McKee T, Linehan W, McMahon J
J Biomol Screen
. 2006 Jul;
11(6):678-87.
PMID: 16858007
Reporter cell lines have been developed for the identification of inhibitors of gene expression enhanced by hypoxia-inducible factor 2, which has been implicated as a transcription factor involved in the...
6.
Riss J, Khanna C, Koo S, Chandramouli G, Yang H, Hu Y, et al.
Cancer Res
. 2006 Jul;
66(14):7216-24.
PMID: 16849569
Cancers have been described as wounds that do not heal, suggesting that the two share common features. By comparing microarray data from a model of renal regeneration and repair (RRR)...
7.
Alleman W, Tabios R, Chandramouli G, Aprelikova O, Torres-Cabala C, Mendoza A, et al.
Clin Cancer Res
. 2004 Oct;
10(20):7011-21.
PMID: 15501981
Purpose: Clear cell renal carcinoma (ccRCC) is strongly associated with loss of the von Hippel-Lindau (VHL) tumor suppressor gene. The VHL gene is functionally lost through hypermethylation in up to...
8.
Aprelikova O, Chandramouli G, Wood M, Vasselli J, Riss J, Maranchie J, et al.
J Cell Biochem
. 2004 May;
92(3):491-501.
PMID: 15156561
Hypoxia and induction of hypoxia-inducible factors (HIF-1alpha and HIF-2alpha) is a hallmark of many tumors. Under normal oxygen tension HIF-alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with...
9.
Maranchie J, Afonso A, Albert P, Kalyandrug S, Phillips J, Zhou S, et al.
Hum Mutat
. 2003 Dec;
23(1):40-6.
PMID: 14695531
von Hippel Lindau disease (VHL) is an autosomal dominant familial cancer syndrome linked to alteration of the VHL tumor suppressor gene. Affected patients are predisposed to develop pheochromocytomas and cystic...
10.
Vasselli J, Shih J, Iyengar S, Maranchie J, Riss J, Worrell R, et al.
Proc Natl Acad Sci U S A
. 2003 Jun;
100(12):6958-63.
PMID: 12777628
To identify potential molecular determinants of tumor biology and possible clinical outcomes, global gene-expression patterns were analyzed in the primary tumors of patients with metastatic renal cell cancer by using...