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James Qu

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Articles 21
Citations 1995
Followers 0
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Recent Articles
1.
Young M, Straub T, Worby C, Metsky H, Gnirke A, Bronson R, et al.
Nat Commun . 2024 Nov; 15(1):9466. PMID: 39487120
Low-abundance members of microbial communities are difficult to study in their native habitats, including Escherichia coli, a minor but common inhabitant of the gastrointestinal tract, and key opportunistic pathogen of...
2.
Young M, Straub T, Worby C, Metsky H, Gnirke A, Bronson R, et al.
bioRxiv . 2024 Mar; PMID: 38463963
Low-abundance members of microbial communities are difficult to study in their native habitats. This includes , a minor, but common inhabitant of the gastrointestinal tract and opportunistic pathogen, including of...
3.
Oguzie J, Petros B, Oluniyi P, Mehta S, Eromon P, Nair P, et al.
Nat Commun . 2023 Aug; 14(1):4693. PMID: 37542071
Effective infectious disease surveillance in high-risk regions is critical for clinical care and pandemic preemption; however, few clinical diagnostics are available for the wide range of potential human pathogens. Here,...
4.
Yao X, Hong J, Nargund A, Ng M, Heng H, Li Z, et al.
Nat Cell Biol . 2023 Apr; 25(5):765-777. PMID: 37095322
PBRM1 encodes an accessory subunit of the PBAF SWI/SNF chromatin remodeller, and the inactivation of PBRM1 is a frequent event in kidney cancer. However, the impact of PBRM1 loss on...
5.
Salamzade R, Manson A, Walker B, Brennan-Krohn T, Worby C, Ma P, et al.
Genome Med . 2022 Apr; 14(1):37. PMID: 35379360
Background: Carbapenem-resistant Enterobacterales (CRE) are an urgent global health threat. Inferring the dynamics of local CRE dissemination is currently limited by our inability to confidently trace the spread of resistance...
6.
Wohl S, Metsky H, Schaffner S, Piantadosi A, Burns M, Lewnard J, et al.
PLoS Biol . 2020 Feb; 18(2):e3000611. PMID: 32045407
Unusually large outbreaks of mumps across the United States in 2016 and 2017 raised questions about the extent of mumps circulation and the relationship between these and prior outbreaks. We...
7.
Metsky H, Siddle K, Gladden-Young A, Qu J, Yang D, Brehio P, et al.
Nat Biotechnol . 2019 Feb; 37(2):160-168. PMID: 30718881
Metagenomic sequencing has the potential to transform microbial detection and characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a computational method to enhance nucleic...
8.
Siddle K, Eromon P, Barnes K, Mehta S, Oguzie J, Odia I, et al.
N Engl J Med . 2018 Oct; 379(18):1745-1753. PMID: 30332564
During 2018, an unusual increase in Lassa fever cases occurred in Nigeria, raising concern among national and international public health agencies. We analyzed 220 Lassa virus genomes from infected patients,...
9.
Barnes K, Kindrachuk J, Lin A, Wohl S, Qu J, Tostenson S, et al.
Clin Infect Dis . 2017 Jun; 65(8):1400-1403. PMID: 28582513
In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent...
10.
Metsky H, Matranga C, Wohl S, Schaffner S, Freije C, Winnicki S, et al.
Nature . 2017 May; 546(7658):411-415. PMID: 28538734
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology...