Hayden C Metsky
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Explore the profile of Hayden C Metsky including associated specialties, affiliations and a list of published articles.
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15
Citations
1551
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Recent Articles
1.
Young M, Straub T, Worby C, Metsky H, Gnirke A, Bronson R, et al.
Nat Commun
. 2024 Nov;
15(1):9466.
PMID: 39487120
Low-abundance members of microbial communities are difficult to study in their native habitats, including Escherichia coli, a minor but common inhabitant of the gastrointestinal tract, and key opportunistic pathogen of...
2.
Mantena S, Pillai P, Petros B, Welch N, Myhrvold C, Sabeti P, et al.
Nat Biotechnol
. 2024 Oct;
PMID: 39394482
CRISPR guide RNA sequences deriving exactly from natural sequences may not perform optimally in every application. Here we implement and evaluate algorithms for designing maximally fit, artificial CRISPR-Cas13a guides with...
3.
Young M, Straub T, Worby C, Metsky H, Gnirke A, Bronson R, et al.
bioRxiv
. 2024 Mar;
PMID: 38463963
Low-abundance members of microbial communities are difficult to study in their native habitats. This includes , a minor, but common inhabitant of the gastrointestinal tract and opportunistic pathogen, including of...
4.
Mantena S, Pillai P, Petros B, Welch N, Myhrvold C, Sabeti P, et al.
bioRxiv
. 2023 Oct;
PMID: 37786711
Generating maximally-fit biological sequences has the potential to transform CRISPR guide RNA design as it has other areas of biomedicine. Here, we introduce model-directed exploration algorithms (MEAs) for designing maximally-fit,...
5.
Metsky H, Welch N, Pillai P, Haradhvala N, Rumker L, Mantena S, et al.
Nat Biotechnol
. 2022 Mar;
40(7):1123-1131.
PMID: 35241837
Design of nucleic acid-based viral diagnostics typically follows heuristic rules and, to contend with viral variation, focuses on a genome's conserved regions. A design process could, instead, directly optimize diagnostic...
6.
Botti-Lodovico Y, Nair P, Nosamiefan D, Stremlau M, Schaffner S, Agignoae S, et al.
Viruses
. 2021 Aug;
13(8).
PMID: 34452470
While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in...
7.
Barnes K, Lachenauer A, Nitido A, Siddiqui S, Gross R, Beitzel B, et al.
Nat Commun
. 2020 Aug;
11(1):4131.
PMID: 32807807
Recent outbreaks of viral hemorrhagic fevers (VHFs), including Ebola virus disease (EVD) and Lassa fever (LF), highlight the urgent need for sensitive, deployable tests to diagnose these devastating human diseases....
8.
Ackerman C, Myhrvold C, Thakku S, Freije C, Metsky H, Yang D, et al.
Nature
. 2020 Apr;
582(7811):277-282.
PMID: 32349121
The great majority of globally circulating pathogens go undetected, undermining patient care and hindering outbreak preparedness and response. To enable routine surveillance and comprehensive diagnostic applications, there is a need...
9.
Wohl S, Metsky H, Schaffner S, Piantadosi A, Burns M, Lewnard J, et al.
PLoS Biol
. 2020 Feb;
18(2):e3000611.
PMID: 32045407
Unusually large outbreaks of mumps across the United States in 2016 and 2017 raised questions about the extent of mumps circulation and the relationship between these and prior outbreaks. We...
10.
Freije C, Myhrvold C, Boehm C, Lin A, Welch N, Carter A, et al.
Mol Cell
. 2019 Oct;
76(5):826-837.e11.
PMID: 31607545
The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA) viruses because it programmably cleaves RNAs complementary to its CRISPR RNA (crRNA). Here, we computationally identify thousands...