James P R Connolly
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Explore the profile of James P R Connolly including associated specialties, affiliations and a list of published articles.
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33
Citations
490
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Recent Articles
1.
Wale K, OBoyle N, McHugh R, Serrano E, Mark D, Douce G, et al.
PLoS Pathog
. 2024 Oct;
20(10):e1012451.
PMID: 39405360
The ability of the attaching and effacing pathogens enterohaemorrhagic Escherichia coli (EHEC) and Citrobacter rodentium to overcome colonisation resistance is reliant on a type 3 secretion system used to intimately...
2.
Cottam C, White R, Beck L, Stewart C, Beatson S, Lowe E, et al.
Nat Commun
. 2024 May;
15(1):4462.
PMID: 38796512
Virulence and metabolism are often interlinked to control the expression of essential colonisation factors in response to host-associated signals. Here, we identified an uncharacterised transporter of the dietary monosaccharide ʟ-arabinose...
3.
Helena-Bueno K, Rybak M, Ekemezie C, Sullivan R, Brown C, Dingwall C, et al.
Nature
. 2024 Feb;
626(8001):1125-1132.
PMID: 38355796
To conserve energy during starvation and stress, many organisms use hibernation factor proteins to inhibit protein synthesis and protect their ribosomes from damage. In bacteria, two families of hibernation factors...
4.
Macdonald E, Wright R, Connolly J, Strahl H, Brockhurst M, van Houte S, et al.
PLoS Genet
. 2023 Jun;
19(6):e1010784.
PMID: 37276233
Competitive bacteria-bacteriophage interactions have resulted in the evolution of a plethora of bacterial defense systems preventing phage propagation. In recent years, computational and bioinformatic approaches have underpinned the discovery of...
5.
OBoyle N, Douce G, Farrell G, Rattray N, Schembri M, Roe A, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2212175120.
PMID: 36574699
The ability of bacterial pathogens to adapt to host niches is driven by the carriage and regulation of genes that benefit pathogenic lifestyles. Genes that encode virulence or fitness-enhancing factors...
6.
Connolly J, Turner N, Serrano E, Rimbi P, Browning D, OBoyle N, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(45):e2210299119.
PMID: 36322762
Ecologically beneficial traits in bacteria are encoded by intrinsic and horizontally acquired genes. However, such traits are not universal, and the highly mosaic nature of bacterial genomes requires control at...
7.
Connolly J, Turner N, Hallam J, Rimbi P, Flett T, McCormack M, et al.
Microbiology (Reading)
. 2021 Oct;
167(10).
PMID: 34623236
Appropriate interpretation of environmental signals facilitates niche specificity in pathogenic bacteria. However, the responses of niche-specific pathogens to common host signals are poorly understood. d-Serine (d-ser) is a toxic metabolite...
8.
An S, Lopes B, Connolly J, Sharp C, Nguyen T, Kirkpatrick C
Microbiology (Reading)
. 2021 Feb;
167(3).
PMID: 33529149
The sixth Young Microbiologists Symposium on 'Microbe Signalling, Organisation and Pathogenesis' was scheduled to be held at the University of Southampton, UK, in late August 2020. However, due to the...
9.
Connolly J, Roe A, OBoyle N
Crit Rev Microbiol
. 2020 Dec;
47(1):126-140.
PMID: 33332206
While evolution proceeds through the generation of random variant alleles, the application of selective pressures can select for subsets of mutations that confer fitness-improving physiological benefits. This, in essence, defines...
10.
OBoyle N, Connolly J, Tucker N, Roe A
Proc Natl Acad Sci U S A
. 2020 Aug;
117(36):22484-22493.
PMID: 32848072
The molecular environment of the host can have profound effects on the behavior of resident bacterial species. We recently established how the sensing and response of enterohemorrhagic (EHEC) to d-serine...