James P Mackay
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Explore the profile of James P Mackay including associated specialties, affiliations and a list of published articles.
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14
Citations
257
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Recent Articles
1.
Cheng J, Koch E, Ramandi D, Mackay J, OLeary T, Rees-Jones W, et al.
Neurobiol Dis
. 2024 Dec;
205():106774.
PMID: 39716682
Background: Altered balance between striatal direct and indirect pathways contributes to early motor, cognitive and psychiatric symptoms in Huntington disease (HD). While degeneration of striatal D2-type dopamine receptor (D2)-expressing indirect...
2.
Nassrallah W, Cheng J, Mackay J, Hogg P, Raymond L
J Neurochem
. 2024 May;
168(9):2671-2689.
PMID: 38770573
Huntington's disease (HD) is a monogenic disorder with autosomal dominant inheritance. In HD patients, neurons in the striatum and cortex degenerate, leading to motor, psychiatric and cognitive disorders. Dysregulated synaptic...
3.
Wang Y, Ramandi D, Sepers M, Mackay J, Raymond L
Hum Mol Genet
. 2023 Nov;
33(5):387-399.
PMID: 37947186
The neurodegenerative disorder, Huntington disease (HD), manifests as disorders of movement, cognition and mood. Although studies report abnormal corticostriatal synaptic function early in HD mouse models, less is known about...
4.
Mackay J, Smith-Dijak A, Koch E, Zhang P, Fung E, Nassrallah W, et al.
J Neurosci
. 2023 Mar;
43(20):3743-3763.
PMID: 36944490
Action potential (AP)-independent (miniature) neurotransmission occurs at all chemical synapses but remains poorly understood, particularly in pathologic contexts. Axonal endoplasmic reticulum (ER) Ca stores are thought to influence miniature neurotransmission,...
5.
Sepers M, Mackay J, Koch E, Xiao D, Mohajerani M, Chan A, et al.
Neurobiol Dis
. 2022 Apr;
169:105740.
PMID: 35460870
Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as progressively impaired movement and cognition. Although early abnormalities of neuronal activity in striatum are well established in HD models, there are...
6.
Michaelson S, Muller T, Bompolaki M, Tapia A, Villarroel H, Mackay J, et al.
Curr Protoc
. 2021 Oct;
1(10):e267.
PMID: 34670009
Organotypic slice cultures (OTCs) have been employed in the laboratory since the early 1980s and have proved to be useful for the study of a number of neural systems. Our...
7.
Michaelson S, Tapia A, McKinty A, Villarroel H, Mackay J, Urban J, et al.
J Neurosci
. 2020 Mar;
40(16):3231-3249.
PMID: 32144180
Endogenous neuropeptide Y (NPY) and corticotrophin-releasing factor (CRF) modulate the responses of the basolateral amygdala (BLA) to stress and are associated with the development of stress resilience and vulnerability, respectively....
8.
Mackay J, Bompolaki M, DeJoseph M, Michaelson S, Urban J, Colmers W
J Neurosci
. 2019 Apr;
39(25):4909-4930.
PMID: 30971438
Although NPY has potent anxiolytic actions within the BLA, selective activation of BLA NPY Y receptors (YRs) acutely increases anxiety by an unknown mechanism. Using male rat brain slice electrophysiology,...
9.
Schmidt M, Buren C, Mackay J, Cheung D, Cengio L, Raymond L, et al.
BMC Biol
. 2018 Jun;
16(1):58.
PMID: 29945611
Background: Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the huntingtin (HTT) gene, leading to selective and progressive neuronal death predominantly in the striatum....
10.
NPY Induces Stress Resilience via Downregulation of in Principal Neurons of Rat Basolateral Amygdala
Villarroel H, Bompolaki M, Mackay J, Tapia A, Michaelson S, Leitermann R, et al.
J Neurosci
. 2018 Apr;
38(19):4505-4520.
PMID: 29650696
Neuropeptide Y (NPY) expression is tightly linked with the development of stress resilience in rodents and humans. Local NPY injections targeting the basolateral amygdala (BLA) produce long-term behavioral stress resilience...