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James OSullivan

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Articles 71
Citations 2361
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Recent Articles
1.
Travesedo J, OSullivan J, Pallegoix L, Huang Z, Hogan P, Goldner P, et al.
Sci Adv . 2025 Mar; 11(10):eadu0581. PMID: 40053599
Pushing the sensitivity of nuclear magnetic resonance spectroscopy to the single spin level would have a major impact in chemistry and biology and is the goal of intense research efforts....
2.
Raghavan V, OSullivan J, Herrero J, Bickel S, Mehta A, Mesgarani N
Imaging Neurosci (Camb) . 2025 Jan; 2. PMID: 39867597
Listeners with hearing loss have trouble following a conversation in multitalker environments. While modern hearing aids can generally amplify speech, these devices are unable to tune into a target speaker...
3.
Burke K, OSullivan J, Godfrey N, Sharma V, Hilton S, Wright S, et al.
J Mol Diagn . 2024 Dec; 27(3):209-215. PMID: 39725012
Pharmacogenetic-guided prescribing can lead to more accurate medicine selection and dosing, improving patient outcomes and leading to better use of health care budgets. Loss-of-function variants in CYP2C19 influence an individual's...
4.
Smith T, Kopajtich R, Demain L, Rea A, Thomas H, Schiff M, et al.
Am J Hum Genet . 2024 Dec; 112(1):59-74. PMID: 39701103
The mitochondrial ribosome (mitoribosome) synthesizes 13 protein subunits of the oxidative phosphorylation system encoded by the mitochondrial genome. The mitoribosome is composed of 12S rRNA, 16S rRNA, and 82 mitoribosomal...
5.
Tiwari R, Sharma R, Rajendran G, Borkowski G, An S, Schonfeld M, et al.
J Clin Invest . 2024 Dec; 135(3). PMID: 39621585
Ischemic acute kidney injury (AKI) is common in hospitalized patients and increases the risk for chronic kidney disease (CKD). Impaired endothelial cell (EC) functions are thought to contribute in AKI...
6.
McDermott J, Burke K, Fullerton N, OSullivan J, Alex A, Ingham A, et al.
QJM . 2024 Oct; PMID: 39418209
Background: Pharmacogenetic guided prescribing can be used to improve the safety and effectiveness of medicines. There are several approaches by which this intervention might be implemented in clinical practice, which...
7.
Haghshenas S, Putoux A, Reilly J, Levy M, Relator R, Ghosh S, et al.
Genet Med . 2024 Aug; 26(10):101226. PMID: 39097820
Purpose: Valproic acid or valproate is an effective antiepileptic drug; however, embryonic exposure to valproate can result in a teratogenic disorder referred to as fetal valproate syndrome (OMIM #609442). Currently...
8.
Belot A, Rice G, Omarjee S, Rouchon Q, Smith E, Moreews M, et al.
Lancet Rheumatol . 2024 Jan; 2(2):e99-e109. PMID: 38263665
Background: Systemic lupus erythematosus (SLE) is a rare immunological disorder and genetic factors are considered important in its causation. Monogenic lupus has been associated with around 30 genotypes in humans...
9.
Kaesler N, Cheng M, Nagai J, OSullivan J, Peisker F, Bindels E, et al.
Sci Adv . 2023 Nov; 9(47):eadj4846. PMID: 38000021
Patients with advanced chronic kidney disease (CKD) mostly die from sudden cardiac death and recurrent heart failure. The mechanisms of cardiac remodeling are largely unclear. To dissect molecular and cellular...
10.
Reuer K, Landgraf J, Fosel T, OSullivan J, Beltran L, Akin A, et al.
Nat Commun . 2023 Nov; 14(1):7138. PMID: 37932251
Realizing the full potential of quantum technologies requires precise real-time control on time scales much shorter than the coherence time. Model-free reinforcement learning promises to discover efficient feedback strategies from...