James Maksymetz
Overview
Explore the profile of James Maksymetz including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
439
Followers
0
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Recent Articles
1.
Gautier O, Blum J, Maksymetz J, Chen D, Schweingruber C, Mei I, et al.
Neuron
. 2023 Dec;
111(23):3739-3741.
PMID: 38061330
No abstract available.
2.
Deng L, Dourado M, Reese R, Huang K, Shields S, Stark K, et al.
Neuron
. 2023 Jun;
111(17):2642-2659.e13.
PMID: 37352856
Loss-of-function mutations in Nav1.7, a voltage-gated sodium channel, cause congenital insensitivity to pain (CIP) in humans, demonstrating that Nav1.7 is essential for the perception of pain. However, the mechanism by...
3.
Jung M, Dourado M, Maksymetz J, Jacobson A, Laufer B, Baca M, et al.
Nat Commun
. 2023 Jan;
14(1):366.
PMID: 36690629
Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of DRGs are conducted in...
4.
Joffe M, Maksymetz J, Luschinger J, Dogra S, Ferranti A, Luessen D, et al.
Neuron
. 2022 Jan;
110(6):1068-1083.e5.
PMID: 35045338
Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited understanding of the molecular and experience-dependent mechanisms that regulate synaptic plasticity across PFC microcircuits. We discovered that mGlu...
5.
Maksymetz J, Byun N, Luessen D, Li B, Barry R, Gore J, et al.
Cell Rep
. 2021 Nov;
37(5):109950.
PMID: 34731619
Evidence for prefrontal cortical (PFC) GABAergic dysfunction is one of the most consistent findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest that the mGlu subtype of...
6.
Moran S, Xiang Z, Doyle C, Maksymetz J, Lv X, Faltin S, et al.
Sci Signal
. 2019 Dec;
12(610).
PMID: 31796631
Highly selective, positive allosteric modulators (PAMs) of the M subtype of muscarinic acetylcholine receptor have emerged as an exciting new approach to potentially improve cognitive function in patients suffering from...
7.
Joffe M, Santiago C, Oliver K, Maksymetz J, Harris N, Engers J, et al.
Neuron
. 2019 Nov;
105(1):46-59.e3.
PMID: 31735403
Non-selective antagonists of metabotropic glutamate receptor subtypes 2 (mGlu) and 3 (mGlu) exert rapid antidepressant-like effects by enhancing prefrontal cortex (PFC) glutamate transmission; however, the receptor subtype contributions and underlying...
8.
Moran S, Maksymetz J, Conn P
Trends Pharmacol Sci
. 2019 Nov;
40(12):1006-1020.
PMID: 31711626
Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex behaviors such as cognition, movement, and reward, making them ideally situated as potential drug targets for the treatment of several...
9.
Xiang Z, Lv X, Maksymetz J, Stansley B, Ghoshal A, Gogliotti R, et al.
ACS Pharmacol Transl Sci
. 2019 Jul;
2(3):198-209.
PMID: 31259318
Metabotropic glutamate (mGlu) receptor type 5 (mGlu) positive allosteric modulators (PAMs) enhance hippocampal long-term potentiation (LTP) and have cognition-enhancing effects in animal models. These effects were initially thought to be...
10.
Maksymetz J, Joffe M, Moran S, Stansley B, Li B, Temple K, et al.
Biol Psychiatry
. 2019 Apr;
85(12):989-1000.
PMID: 31003787
Background: The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In psychiatric disorders such as posttraumatic stress disorder,...