James M Angelastro
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Explore the profile of James M Angelastro including associated specialties, affiliations and a list of published articles.
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30
Citations
893
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Recent Articles
21.
Schrot R, Ma J, Greco C, Arias A, Angelastro J
J Neurooncol
. 2007 May;
85(2):149-57.
PMID: 17516028
The role of stem cells in the origin, growth patterns, and infiltration of glioblastoma multiforme is a subject of intense investigation. One possibility is that glioblastoma may arise from transformed...
22.
Monaco S, Angelastro J, Szabolcs M, Greene L
Int J Cancer
. 2007 Feb;
120(9):1883-90.
PMID: 17266024
ATF5, a transcription factor important in differentiation, proliferation and survival, has been found to be highly expressed in neural progenitor cells and in certain tumors including glioblastomas (GBMs), but its...
23.
Greene L, Angelastro J
Neurochem Res
. 2005 Dec;
30(10):1347-52.
PMID: 16341597
Here we review findings indicating that neurotrophins such as NGF promote changes in gene transcription that in turn influence the ways that cells subsequently respond to trophic factors. As a...
24.
Mason J, Angelastro J, Ignatova T, Kukekov V, Lin G, Greene L, et al.
Mol Cell Neurosci
. 2005 Jun;
29(3):372-80.
PMID: 15950153
The transcription factor ATF5 is expressed in cells of the embryonic and neonatal ventricular zone/subventricular zone (VZ/SVZ), and must be down-regulated for their differentiation into neurons and astrocytes. Here, we...
25.
Angelastro J, Mason J, Ignatova T, Kukekov V, Stengren G, Goldman J, et al.
J Neurosci
. 2005 Apr;
25(15):3889-99.
PMID: 15829641
The mechanisms that regulate neural progenitor cell differentiation are primarily unknown. The transcription factor activating transcription factor 5 (ATF5) is expressed in neural progenitors of developing brain but is absent...
26.
Ryu E, Angelastro J, Greene L
Neurobiol Dis
. 2005 Jan;
18(1):54-74.
PMID: 15649696
We employed Serial Analysis of Gene Expression to identify transcriptional changes in a cellular model of Parkinson Disease (PD). The model consisted of neuronally differentiated PC12 cells compared before and...
27.
Angelastro J, Ignatova T, Kukekov V, Steindler D, Stengren G, Mendelsohn C, et al.
J Neurosci
. 2003 Jun;
23(11):4590-600.
PMID: 12805299
An important milestone in brain development is the transition of neuroprogenitor cells to postmitotic neurons. We report that the bZIP transcription factor ATF5 plays a major regulatory role in this...
28.
Ryu E, Harding H, Angelastro J, Vitolo O, Ron D, Greene L
J Neurosci
. 2002 Dec;
22(24):10690-8.
PMID: 12486162
6-hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP+), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to model Parkinson's disease. To identify regulated genes in such...
29.
Torocsik B, Angelastro J, Greene L
J Neurosci
. 2002 Oct;
22(20):8971-80.
PMID: 12388604
We used serial analysis of gene expression to identify new NGF-responsive immediate early genes (IEGs) with potential roles in neuronal differentiation. Among those identified was MafK, a small Maf family...
30.
Angelastro J, Torocsik B, Greene L
BMC Neurosci
. 2002 Apr;
3:3.
PMID: 11922865
Background: NGF exerts a variety of actions including promotion of neuronal differentiation and survival. The PC12 rat pheochromocytoma cell line has proved valuable for studying how NGF works and has...