James L Funderburgh
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Explore the profile of James L Funderburgh including associated specialties, affiliations and a list of published articles.
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62
Citations
2233
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Recent Articles
1.
Palchesko R, Du Y, Geary M, Carrasquilla S, Shiwarski D, Khandaker I, et al.
Commun Mater
. 2024 Aug;
3(1).
PMID: 39175945
Cell injection is a common clinical approach for therapeutic delivery into diseased and damaged tissues in order to achieve regeneration. However, cell retention, viability, and engraftment at the injection site...
2.
Dos Santos A, Lyu N, Balayan A, Knight R, Zhuo K, Sun Y, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362184
In addition to their therapeutic potential in regenerative medicine, human corneal stromal stem cells (CSSCs) could serve as a powerful tool for drug discovery and development. Variations from different donors,...
3.
Yam G, Yang T, Geary M, Santra M, Funderburgh M, Rubin E, et al.
J Adv Res
. 2022 May;
45:141-155.
PMID: 35623612
Introduction: Corneal blindness due to scarring is treated with corneal transplantation. However, a global problem is the donor material shortage. Preclinical and clinical studies have shown that cell-based therapy using...
4.
Weng L, Funderburgh J, Khandaker I, Geary M, Yang T, Basu R, et al.
Eye Vis (Lond)
. 2020 Dec;
7(1):52.
PMID: 33292650
Background: Corneal stromal stem cells (CSSC) reduce corneal inflammation, prevent fibrotic scarring, and regenerate transparent stromal tissue in injured corneas. These effects rely on factors produced by CSSC to block...
5.
Khandaker I, Funderburgh J, Geary M, Funderburgh M, Jhanji V, Du Y, et al.
Exp Eye Res
. 2020 Sep;
200:108270.
PMID: 32979396
Corneal opacities affect vision for millions of individuals worldwide. Fibrotic scar tissues accumulate in reaction to inflammatory responses and remain permanently in corneal stroma, and conventionally correctable only by donor...
6.
Dos Santos A, Balayan A, Funderburgh M, Ngo J, Funderburgh J, Deng S
Invest Ophthalmol Vis Sci
. 2019 Jul;
60(8):3013-3023.
PMID: 31310658
Purpose: Mesenchymal stem cells (MSCs) have been extensively studied for their capacity to enhance wound healing and represent a promising research field for generating cell therapies for corneal scars. In...
7.
Shojaati G, Khandaker I, Funderburgh M, Mann M, Basu R, Stolz D, et al.
Stem Cells Transl Med
. 2019 Jul;
8(11):1192-1201.
PMID: 31290598
Mesenchymal stem cells from corneal stromal stem cells (CSSC) prevent fibrotic scarring and stimulate regeneration of transparent stromal tissue after corneal wounding in mice. These effects rely on the ability...
8.
Deardorff P, McKay T, Wang S, Ghezzi C, Cairns D, Abbott R, et al.
Sci Rep
. 2018 Nov;
8(1):17294.
PMID: 30470798
Diabetes mellitus is a disease caused by innate or acquired insulin deficiency, resulting in altered glucose metabolism and high blood glucose levels. Chronic hyperglycemia is linked to development of several...
9.
Siran W, Ghezzi C, Cairns D, Pollard R, Chen Y, Gomes R, et al.
Adv Healthc Mater
. 2018 Aug;
7(19):e1800488.
PMID: 30091220
New in vitro tissue models to mimic in vivo conditions are needed to provide insight into mechanisms involved in peripheral pain responses, potential therapeutic strategies to address these responses, and...
10.
Shojaati G, Khandaker I, Sylakowski K, Funderburgh M, Du Y, Funderburgh J
Stem Cells Transl Med
. 2018 Apr;
7(6):487-494.
PMID: 29654654
Stem cells from human corneal stroma (CSSC) suppress corneal stromal scarring in a mouse wound-healing model and promote regeneration of native transparent tissue (PMID:25504883). This study investigated efficacy of compressed...