James K Chen
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Explore the profile of James K Chen including associated specialties, affiliations and a list of published articles.
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77
Citations
4500
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Recent Articles
1.
Feng Z, Hom M, Bearrood T, Rosenthal Z, Fernandez D, Ondrus A, et al.
Nat Chem Biol
. 2024 Dec;
21(2):309.
PMID: 39653787
No abstract available.
2.
Zhang M, Chapman M, Sarode B, Xiong B, Liang H, Chen J, et al.
Nature
. 2024 Aug;
633(8028):90-95.
PMID: 39169193
Although aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug. Nonoptimal potency, metabolic stability,...
3.
Darrah K, Albright S, Kumbhare R, Tsang M, Chen J, Deiters A
ACS Chem Biol
. 2023 Jun;
18(10):2176-2182.
PMID: 37326511
The structure and mechanism of the bacterial enzyme β-lactamase have been well-studied due to its clinical role in antibiotic resistance. β-Lactamase is known to hydrolyze the β-lactam ring of the...
4.
Pattanayak S, Sarode B, Deiters A, Chen J
Chembiochem
. 2022 Sep;
23(21):e202200374.
PMID: 36068175
Caged morpholino oligonucleotides (cMOs) are synthetic tools that allow light-inducible gene silencing in live organisms. Previously reported cMOs have utilized hairpin, duplex, and cyclic structures, as well as caged nucleobases....
5.
Feng Z, Hom M, Bearrood T, Rosenthal Z, Fernandez D, Ondrus A, et al.
Nat Chem Biol
. 2022 Jul;
18(10):1065-1075.
PMID: 35788181
Aldehyde dehydrogenases (ALDHs) are promising cancer drug targets, as certain isoforms are required for the survival of stem-like tumor cells. We have discovered selective inhibitors of ALDH1B1, a mitochondrial enzyme...
6.
Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction
Darrah K, Wesalo J, Lukasak B, Tsang M, Chen J, Deiters A
J Am Chem Soc
. 2021 Oct;
143(44):18665-18671.
PMID: 34705461
Conditionally activated, caged morpholino antisense agents (cMOs) are tools that enable the temporal and spatial investigation of gene expression, regulation, and function during embryonic development. Cyclic MOs are conformationally gated...
7.
Xu J, Zheng X, Feng Z, Lu Z, Zhang Z, Huang W, et al.
Nat Sustain
. 2021 Aug;
4:233-241.
PMID: 34355066
The presence of organic contaminants in wastewater poses considerable risks to the health of both humans and ecosystems. Although advanced oxidation processes that rely on highly reactive radicals to destroy...
8.
Nano P, Johnson T, Kudo T, Mooney N, Ni J, Demeter J, et al.
PLoS One
. 2021 May;
16(5):e0251684.
PMID: 33999959
ARHGAP36 is an atypical Rho GTPase-activating protein (GAP) family member that drives both spinal cord development and tumorigenesis, acting in part through an N-terminal motif that suppresses protein kinase A...
9.
Cho U, Chen J
Cell Chem Biol
. 2020 Aug;
27(8):921-936.
PMID: 32735780
The unique photophysical properties of lanthanides, such as europium, terbium, and ytterbium, make them versatile molecular probes of biological systems. In particular, their long-lived photoluminescence, narrow bandwidth emissions, and large...
10.
Ciepla P, Cho U, Chen J
Methods Enzymol
. 2020 Jun;
640:225-248.
PMID: 32560800
In principle, the long emission lifetimes of lanthanide chelates should enable their ultrasensitive detection in biological systems by time-resolved optical microscopy. However, most lanthanide-imaging systems cannot achieve sensitivities that exceed...