Paul G Rack
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Explore the profile of Paul G Rack including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
498
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0
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Recent Articles
1.
Hom M, Ondrus A, Sakata-Kato T, Rack P, Chen J
ChemMedChem
. 2020 Apr;
15(12):1044-1049.
PMID: 32268014
Gli transcription factors within the Hedgehog (Hh) signaling pathway direct key events in mammalian development and promote a number of human cancers. Current therapies for Gli-driven tumors target Smoothened (SMO),...
2.
Aaron Crapster J, Rack P, Hellmann Z, Le A, Adams C, Leib R, et al.
Elife
. 2020 Mar;
9.
PMID: 32163033
Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are not well understood, and we demonstrate here...
3.
Thissen J, Be N, McLoughlin K, Gardner S, Rack P, Shapero M, et al.
PLoS One
. 2019 Feb;
14(2):e0212045.
PMID: 30735540
Microarrays have proven to be useful in rapid detection of many viruses and bacteria. Pathogen detection microarrays have been used to diagnose viral and bacterial infections in clinical samples and...
4.
Mich J, Payumo A, Rack P, Chen J
PLoS One
. 2014 Jul;
9(7):e103661.
PMID: 25068273
The Hedgehog (Hh) pathway is essential for embryonic development and tissue regeneration, and its dysregulation can lead to birth defects and tumorigenesis. Understanding how this signaling mechanism contributes to these...
5.
Rack P, Ni J, Payumo A, Nguyen V, Aaron Crapster J, Hovestadt V, et al.
Proc Natl Acad Sci U S A
. 2014 Jul;
111(30):11061-6.
PMID: 25024229
Hedgehog (Hh) pathway activation and Gli-dependent transcription play critical roles in embryonic patterning, tissue homeostasis, and tumorigenesis. By conducting a genome-scale cDNA overexpression screen, we have identified the Rho GAP...
6.
Li X, Nadauld L, Ootani A, Corney D, Pai R, Gevaert O, et al.
Nat Med
. 2014 May;
20(7):769-77.
PMID: 24859528
The application of primary organoid cultures containing epithelial and mesenchymal elements to cancer modeling holds promise for combining the accurate multilineage differentiation and physiology of in vivo systems with the...
7.
Hyman J, Firestone A, Heine V, Zhao Y, Ocasio C, Han K, et al.
Proc Natl Acad Sci U S A
. 2009 Aug;
106(33):14132-7.
PMID: 19666565
Inappropriate activation of the Hedgehog (Hh) signaling pathway has been implicated in a diverse spectrum of cancers, and its pharmacological blockade has emerged as an anti-tumor strategy. While nearly all...
8.
Cupido T, Rack P, Firestone A, Hyman J, Han K, Sinha S, et al.
Angew Chem Int Ed Engl
. 2009 Feb;
48(13):2321-4.
PMID: 19222062
Eradicating hedgehogs: The title molecule has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This molecule is...