James J Folmer
Overview
Explore the profile of James J Folmer including associated specialties, affiliations and a list of published articles.
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4
Citations
29
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Recent Articles
1.
Brown D, Bernstein P, Griffin A, Wesolowski S, Labrecque D, Tremblay M, et al.
J Med Chem
. 2014 Jan;
57(3):733-58.
PMID: 24410637
A new series of potent and selective histamine-3 receptor (H3R) antagonists was identified on the basis of an azaspiro[2.5]octane carboxamide scaffold. Many scaffold modifications were largely tolerated, resulting in nanomolar-potent...
2.
Yu J, Folmer J, Hoesch V, Doherty J, Campbell J, Burdette D
Drug Metab Dispos
. 2010 Nov;
39(2):302-11.
PMID: 21045198
Studies on the biotransformation of isoxazole rings have shown that molecules containing a C3-substituted isoxazole or a 1,2-benzisoxazole can undergo a two-electron reductive ring cleavage to form an imine. In...
3.
Brugel T, Smith R, Balestra M, Becker C, Daniels T, Hoerter T, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(19):5847-52.
PMID: 20727752
Initial high throughput screening efforts identified highly potent and selective kappa opioid receptor antagonist 3 (κ IC(50)=77 nM; μ:κ and δ:κ IC(50) ratios>400) which lacked CNS exposure in vivo. Modification...
4.
Scott C, Sobotka-Briner C, Wilkins D, Jacobs R, Folmer J, Frazee W, et al.
J Pharmacol Exp Ther
. 2002 Dec;
304(1):433-40.
PMID: 12490620
Caspase-3 is an intracellular cysteine protease, activated as part of the apoptotic response to cell injury. Its interest as a therapeutic target has led many to pursue the development of...