James J Cai
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Explore the profile of James J Cai including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Chen B, Lin C, Wu H, Cai J, Chao D
Microbiol Spectr
. 2024 Mar;
12(4):e0395423.
PMID: 38483513
Coronaviruses (CoVs), including severe acute respiratory syndrome coronavirus 2, can infect a variety of mammalian and avian hosts with significant medical and economic consequences. During the life cycle of CoV,...
12.
Ferrer P, Upadhyay S, Cai J, Clement T
bioRxiv
. 2024 Mar;
PMID: 38464253
A mechanistic role for nuclear function of testis-specific actin related proteins (ARPs) is proposed here through contributions of ARP subunit swapping in canonical chromatin regulatory complexes. This is significant to...
13.
Zhou F, He K, Cai J, Davidson L, Chapkin R, Ni Y
Stat Biosci
. 2024 Jan;
15(3):669-691.
PMID: 38179127
The advances of modern sequencing techniques have generated an unprecedented amount of multi-omics data which provide great opportunities to quantitatively explore functional genomes from different but complementary perspectives. However, distinct...
14.
Ahmad I, Gupta S, Faulkner P, Mullens D, Thomas M, Sytha S, et al.
bioRxiv
. 2023 Nov;
PMID: 37961306
Coronary artery disease (CAD) is a leading cause of death in women. Although exercise mitigates CAD, the mechanisms by which exercise impacts epicardial adipose tissue (EAT) are unknown. We hypothesized...
15.
Yang Y, Lin Y, Li G, Zhong Y, Xu Q, Cai J
Brief Bioinform
. 2023 Oct;
24(6).
PMID: 37798250
Cell-surface proteins play a critical role in cell function and are primary targets for therapeutics. CITE-seq is a single-cell technique that enables simultaneous measurement of gene and surface protein expression....
16.
Yang W, Kim D, Jiang W, Ai W, Pan Q, Rahman S, et al.
Aging Cell
. 2023 Aug;
22(10):e13968.
PMID: 37602516
The liver is a key metabolic organ that maintains whole-body nutrient homeostasis. Aging-induced liver function alterations contribute to systemic susceptibility to aging-related diseases. However, the molecular mechanisms of liver aging...
17.
Yang Y, Li G, Zhong Y, Xu Q, Chen B, Lin Y, et al.
Nucleic Acids Res
. 2023 May;
51(13):6578-6592.
PMID: 37246643
In this paper, we introduce Gene Knockout Inference (GenKI), a virtual knockout (KO) tool for gene function prediction using single-cell RNA sequencing (scRNA-seq) data in the absence of KO samples...
18.
Yang Y, Li G, Zhong Y, Xu Q, Lin Y, Roman-Vicharra C, et al.
Cell Syst
. 2023 Feb;
14(4):302-311.e4.
PMID: 36787742
We present scTenifoldXct, a semi-supervised computational tool for detecting ligand-receptor (LR)-mediated cell-cell interactions and mapping cellular communication graphs. Our method is based on manifold alignment, using LR pairs as inter-data...
19.
Li H, Zheng J, Xu Q, Yang Y, Zhou J, Guo X, et al.
Gastroenterology
. 2022 Oct;
164(1):134-146.
PMID: 36181835
Background & Aims: Nonalcoholic fatty liver disease is highly associated with obesity and progresses to nonalcoholic steatohepatitis when the liver develops overt inflammatory damage. While removing adenosine in the purine...
20.
Doke M, McLaughlin J, Cai J, Pendyala G, Kashanchi F, Khan M, et al.
Mol Ther Nucleic Acids
. 2022 Jul;
29:243-258.
PMID: 35892093
Clinical research has proven that HIV-positive (HIV) individuals with cocaine abuse show behavioral and neurocognitive disorders. Noncoding RNAs (ncRNAs), such as long ncRNAs (lncRNAs) and microRNAs (miRNAs), are known to...