James H Kurasawa
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Explore the profile of James H Kurasawa including associated specialties, affiliations and a list of published articles.
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8
Citations
52
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Recent Articles
1.
McMurphy T, Park A, Heizer P, Bottenfield C, Kurasawa J, Ikeda Y, et al.
Sci Rep
. 2024 Nov;
14(1):28853.
PMID: 39572604
Adeno-associated virus (AAV) vectors can mediate long-term expression of immunogenic transgenes in vivo through transduction of tolerogenic cells in the liver. Tissue-targeted AAV vectors allow transduction of non-hepatic cells, but...
2.
Chun H, Kurasawa J, Olivares P, Marakasova E, Shestopal S, Hassink G, et al.
J Thromb Haemost
. 2022 Jul;
20(10):2255-2269.
PMID: 35810466
Background: Deficiency in blood coagulation factor VIII (FVIII) results in life-threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve disease treatment, FVIII has been modified to increase...
3.
Marakasova E, Olivares P, Karnaukhova E, Chun H, Hernandez N, Kurasawa J, et al.
J Biol Chem
. 2021 May;
297(1):100842.
PMID: 34058195
The low-density lipoprotein receptor (LDLR) family of receptors are cell-surface receptors that internalize numerous ligands and play crucial role in various processes, such as lipoprotein metabolism, hemostasis, fetal development, etc....
4.
Kurasawa J, Park A, Sowers C, Halpin R, Tovchigrechko A, Dobson C, et al.
Mol Ther Methods Clin Dev
. 2020 Nov;
19:330-340.
PMID: 33145369
The recombinant adeno-associated virus (AAV) vector is one of the most utilized viral vectors in gene therapy due to its robust, long-term transgene expression and low toxicity. One major hurdle...
5.
Podoplelova N, Sveshnikova A, Kurasawa J, Sarafanov A, Chambost H, Vasilev S, et al.
Biochim Biophys Acta
. 2016 Feb;
1858(6):1216-27.
PMID: 26874201
Binding of coagulation factors X (fX) and Xa (fXa) to activated platelets is required for the formation of membrane-dependent enzymatic complexes of intrinsic tenase and prothrombinase. We carried out an...
6.
Kurasawa J, Shestopal S, Woodle S, Ovanesov M, Lee T, Sarafanov A
Biochemistry
. 2014 Dec;
54(2):481-9.
PMID: 25486042
Low-density lipoprotein receptor-related protein 1 (LRP) mediates clearance of blood coagulation factor VIII (FVIII). In LRP, FVIII binds the complement-type repeats (CRs) of clusters II and IV, which also bind...
7.
Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII
Kurasawa J, Shestopal S, Karnaukhova E, Struble E, Lee T, Sarafanov A
J Biol Chem
. 2013 Jun;
288(30):22033-41.
PMID: 23754288
Low density lipoprotein receptor (LDLR) was shown to mediate clearance of blood coagulation factor VIII (FVIII) from the circulation. To elucidate the mechanism of interaction of LDLR and FVIII, our...
8.
Kurasawa J, Shestopal S, Jha N, Ovanesov M, Lee T, Sarafanov A
Protein Expr Purif
. 2013 Jan;
88(2):201-6.
PMID: 23306063
A recombinant single-chain variable antibody fragment (scFv) KM33 was previously described as a ligand that can inhibit the function of blood coagulation factor VIII (FVIII). This scFv was previously derived...