James E Vince
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Explore the profile of James E Vince including associated specialties, affiliations and a list of published articles.
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81
Citations
4794
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Recent Articles
1.
Saller B, Wohrle S, Fischer L, Dufossez C, Ingerl I, Kessler S, et al.
Immunity
. 2024 Nov;
58(1):90-107.e11.
PMID: 39571574
How mitochondria reconcile roles in functionally divergent cell death pathways of apoptosis and NLRP3 inflammasome-mediated pyroptosis remains elusive, as is their precise role in NLRP3 activation and the evolutionarily conserved...
2.
Tye H, Conos S, Djajawi T, Gottschalk T, Abdoulkader N, Kong I, et al.
Life Sci Alliance
. 2024 Nov;
8(1).
PMID: 39532538
Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction-associated fatty liver disease (MAFLD). However, the exact contribution of core cell death machinery to disease manifestations remains ill-defined....
3.
Anderton H, Bandala-Sanchez E, Simpson D, Rickard J, Ng A, Di Rago L, et al.
Cell Death Differ
. 2024 Nov;
31(12):1776-1777.
PMID: 39511406
No abstract available.
4.
Lee C, Park M, Wijesinghe W, Na S, Lee C, Hwang E, et al.
Nat Commun
. 2024 May;
15(1):4025.
PMID: 38740804
Intracellular membranes composing organelles of eukaryotes include membrane proteins playing crucial roles in physiological functions. However, a comprehensive understanding of the cellular responses triggered by intracellular membrane-focused oxidative stress remains...
5.
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation
Tran H, Kratina T, Coutansais A, Michalek D, Hogan B, Lawlor K, et al.
Cell Death Differ
. 2024 Mar;
31(5):662-671.
PMID: 38514849
Caspase-8 activity is required to inhibit necroptosis during embryogenesis in mice. In vitro studies have suggested that caspase-8 directly cleaves RIPK1, CYLD and the key necroptotic effector kinase RIPK3 to...
6.
Lawlor K, Murphy J, Vince J
Immunity
. 2024 Mar;
57(3):429-445.
PMID: 38479360
Diverse inflammatory conditions, from infections to autoimmune disease, are often associated with cellular damage and death. Apoptotic cell death has evolved to minimize its inflammatory potential. By contrast, necrotic cell...
7.
Vince J
J Cell Biol
. 2024 Feb;
223(3).
PMID: 38329462
TNF signaling does not result in cell death unless multiple inhibitory signals are overcome, which can be accomplished by simultaneous signaling through IFNγ. In this issue, Deng and colleagues (http://doi.org/10.1083/jcb.202305026)...
8.
Simpson D, Anderton H, Yousef J, Vaibhav V, Cobbold S, Bandala-Sanchez E, et al.
PNAS Nexus
. 2023 Dec;
3(1):pgad438.
PMID: 38156288
Skin inflammation is a complex process implicated in various dermatological disorders. The chronic proliferative dermatitis (cpd) phenotype driven by the cpd mutation (cpdm) in the Sharpin gene is characterized by...
9.
Meza Guzman L, Hyland C, Bidgood G, Leong E, Shen Z, Goh W, et al.
Immunol Cell Biol
. 2023 Oct;
102(1):58-70.
PMID: 37855066
The clinical development of Natural Killer (NK) cell-mediated immunotherapy marks a milestone in the development of new cancer therapies and has gained traction due to the intrinsic ability of the...
10.
Speir M, Tye H, Gottschalk T, Simpson D, Djajawi T, Deo P, et al.
EMBO Rep
. 2023 Oct;
24(11):e56865.
PMID: 37846472
Programmed cell death pathways play an important role in innate immune responses to infection. Activation of intrinsic apoptosis promotes infected cell clearance; however, comparatively little is known about how this...