James E Mahaney
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Explore the profile of James E Mahaney including associated specialties, affiliations and a list of published articles.
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15
Citations
244
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Recent Articles
1.
Kang L, Rashkovetsky E, Michalak K, Garner H, Mahaney J, Rzigalinski B, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(24):11839-11844.
PMID: 31127048
Biodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent...
2.
Keceli G, Majumdar A, Thorpe C, Jun S, Tocchetti C, Lee D, et al.
J Gen Physiol
. 2019 Mar;
151(6):758-770.
PMID: 30842219
Nitroxyl (HNO) positively modulates myocardial function by accelerating Ca reuptake into the sarcoplasmic reticulum (SR). HNO-induced enhancement of myocardial Ca cycling and function is due to the modification of cysteines...
3.
Sivakumaran V, Stanley B, Tocchetti C, Ballin J, Caceres V, Zhou L, et al.
Antioxid Redox Signal
. 2013 Aug;
19(11):1185-97.
PMID: 23919584
Aims: Nitroxyl (HNO) interacts with thiols to act as a redox-sensitive modulator of protein function. It enhances sarcoplasmic reticular Ca(2+) uptake and myofilament Ca(2+) sensitivity, improving cardiac contractility. This activity...
4.
Fu W, Zhang J, Fuhrer T, Champion H, Furukawa K, Kato T, et al.
J Am Chem Soc
. 2011 May;
133(25):9741-50.
PMID: 21548647
The dimetallic endohedral heterofullerene (EHF), Gd(2)@C(79)N, was prepared and isolated in a relatively high yield when compared with the earlier reported heterofullerene, Y(2)@C(79)N. Computational (DFT), chemical reactivity, Raman, and electrochemical...
5.
Froehlich J, Mahaney J, Keceli G, Pavlos C, Goldstein R, Redwood A, et al.
Biochemistry
. 2008 Dec;
47(50):13150-2.
PMID: 19053265
Nitroxyl (HNO) donated by Angeli's salt activates uptake of Ca(2+) by the cardiac SR Ca(2+) pump (SERCA2a). To determine whether HNO achieves this by a direct interaction with SERCA2a or...
6.
Mahaney J, Thomas D, Farrance I, Froehlich J
Biochemistry
. 2008 Dec;
47(51):13711-25.
PMID: 19046074
Native membrane sarcoplasmic reticulum (SR) Ca(2+)-ATPase isolated from skeletal muscle (SERCA1) exhibits oligomeric kinetic behavior [Mahaney, J. E., Thomas, D. D., and Froehlich, J. P. (2004) Biochemistry 43, 4400-4416]. In...
7.
Chen B, Mahaney J, Mayer M, Bigelow D, Squier T
Biochemistry
. 2008 Oct;
47(47):12448-56.
PMID: 18956892
Calcium-dependent domain movements of the actuator (A) and nucleotide (N) domains of the SERCA2a isoform of the Ca-ATPase were assessed using constructs containing engineered tetracysteine binding motifs, which were expressed...
8.
Jia Z, Zhu H, Misra B, Mahaney J, Li Y, Misra H
Mol Cell Biochem
. 2008 Apr;
313(1-2):187-94.
PMID: 18409032
Resveratrol (3,4',5-trihydroxystilbene), a polyphenolic compound found in mulberries, grapes, and red wine, has received considerable attention because of its apparent protective effects against various degenerative diseases due to its potential...
9.
Zhu H, Jia Z, Mahaney J, Ross D, Misra H, Trush M, et al.
Cardiovasc Toxicol
. 2007 Sep;
7(3):202-11.
PMID: 17901563
It has recently been demonstrated that purified NAD(P)H:quinone oxidoreductase 1 (NQO1) is able to scavenge superoxide (O2(.-)) though the rate of reaction of O2(.-) with NQO1 is much lower than...
10.
Waggoner J, Huffman J, Froehlich J, Mahaney J
Biochemistry
. 2007 Jan;
46(7):1999-2009.
PMID: 17261028
We have used steady-state fluorescence spectroscopy in combination with enzyme kinetic assays to test the hypothesis that phospholamban (PLB) stabilizes the Ca-ATPase in the E2 intermediate state. The cardiac muscle...